PMID: 6602161Jul 1, 1983Paper

The biologic activity of mast cell granules. V. The effects of antihistamine treatment on rat cutaneous early- and late-phase allergic reactions

The Journal of Allergy and Clinical Immunology
R F LemanskeM Kaliner

Abstract

Mast cell-dependent late-phase allergic reactions (LPR) as sequelae of immediate hypersensitivity responses (IR) occur in both human and rat skin; thus the rat has served as a useful model to investigate the pathogenesis of cutaneous LPR. To analyze the roles that histamine might play in the generation of rat LPR, the effects of H1 and/or H2 antihistamines on both LPR and antecedent blueing responses (IR) were investigated. Systemically administered diphenhydramine and cimetidine, alone or in combination, reduced blueing reactions to histamine. However, blueing responses to anti-IgE were only partially abrogated by antihistamine treatment with diphenhydramine alone or the combination of antihistamines. Diphenhydramine treatment alone partially inhibited the histologic intensity of LPR in a dose-dependent manner. Although cimetidine treatment alone had no inhibitory effect, it potentiated the diphenhydramine-induced inhibition of LPR. The inhibitory action of antihistamine treatment was apparent only in reactions elicited by anti-IgE or mast cell granules containing histamine, since LPR caused by histamine-free mast cell granules were not affected by antihistamines. This observation suggests that the inhibitory effect of antihis...Continue Reading

References

Sep 1, 1978·Experimental Cell Research·G D RaphaelM Kaliner
Aug 1, 1976·The Journal of Clinical Investigation·G O SolleyA L Schroeter
Jul 1, 1976·The Journal of Allergy and Clinical Immunology·L UmemotoF E Hargreave
Feb 1, 1976·The Journal of Allergy and Clinical Immunology·J PoothullilR P Day
Jul 1, 1973·The Journal of Allergy and Clinical Immunology·J DolovichJ Bienenstock
May 1, 1973·The Journal of Allergy and Clinical Immunology·P AtkinsB Zweiman

❮ Previous
Next ❯

Citations

May 1, 1993·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·W A MasseyL M Lichtenstein
Jan 1, 1989·The Journal of Clinical Investigation·R F LemanskeW W Busse
Jan 1, 1986·Toxicon : Official Journal of the International Society on Toxinology·J W Burnett, G J Calton
Nov 17, 2007·The Journal of Investigative Dermatology·Edward PelleDaniel Maes
Jun 1, 1984·The Journal of Allergy and Clinical Immunology·J FarnamE R Petrusa
Dec 1, 1987·Immunological Investigations·R M NaclerioD Proud

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.