PMID: 7541293Jul 1, 1995Paper

The biologic behavior of balloon hyperinflation-induced arterial lesions in hypercholesterolemic pigs depends on the presence of foam cells

Arteriosclerosis, Thrombosis, and Vascular Biology
D RecchiaS A Wickline

Abstract

Lack of a large-animal model of accelerated atherosclerosis has limited study of the biologic behavior of atherosclerotic lesions. We hypothesized that mechanical vascular trauma combined with diet-induced hypercholesterolemia would result in rapid development of complex atherosclerosis-like lesions. Accordingly, we induced deep injury to a carotid artery by repetitive balloon hyperinflations in minipigs that were fed either an atherogenic diet (n = 30) or a standard diet (controls, n = 4) and examined the resultant lesions 1 month later. The neointimal lesions that evolved in 23 patent vessels from cholesterol-fed animals were complex, exhibiting infiltration of smooth muscle and foam cells and evidence of organized thrombus, recent thrombus, hemorrhage, and calcification. Lesions were separable histologically into two groups: foam-cell rich (n = 12), with 33 +/- 10 foam cells per high-power field, and foam-cell poor (n = 11), with 4 +/- 1 foam cells per high-power field. Minipigs with foam cell-rich lesions had higher serum cholesterol levels than those with foam cell-poor lesions (712 +/- 178 vs 468 +/- 240 mg/dL, P < .02). The incidence of intralesional thrombus was also significantly greater in foam cell-rich than in foam ...Continue Reading

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Citations

Dec 24, 1997·Journal of Magnetic Resonance Imaging : JMRI·W LinE M Haacke
Dec 23, 1998·Atherosclerosis·R L ReddickN Maeda
Dec 1, 1996·Journal of the American College of Cardiology·D R AbendscheinP R Eisenberg
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Jan 18, 2006·FEBS Letters·Yao-Ching HungG Steve Huang
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·W LinE M Haacke
Nov 13, 2014·Journal of Biomedical Optics·Dolonchampa MajiMonica Shokeen
Jun 8, 2006·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Tillmann CyrusGregory M Lanza

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