PMID: 7087822Mar 1, 1982Paper

The biologic significance of neutrophil regulatory mechanisms

Medical Hypotheses
Y H Thong

Abstract

Self-regulation of feedback control are essential features of most complex biological systems. Neutrophil leukocytes possess potent oxidative and lysomal products for the killing of invading microbes. These toxic products are also capable of causing auto-oxidative injury and tissue damage. Indeed, neutrophils have been implicated as mediators of tissue injury in a number of autoimmune and inflammatory disorders. It is proposed that a sophisticated and complex regulatory mechanism for neutrophil function is operative in healthy individuals. Much of the evidence for this is tentative and fragmentary, but a logical framework is beginning to emerge.

References

Oct 1, 1978·The Journal of Experimental Medicine·H E BroxmeyerM de Sousa
May 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·L J Ignarro, W J George
Nov 1, 1972·The Journal of Clinical Investigation·D W Golde, M J Cline
Jan 1, 1969·Proceedings of the National Academy of Sciences of the United States of America·M ParanL Sachs
Jul 3, 1980·The New England Journal of Medicine·G WeissmannH M Korchak
Jul 2, 1981·The New England Journal of Medicine·J V White
Aug 1, 1965·The Journal of Experimental Medicine·P A WARDH J MUELLER-EBERHARD

Citations

May 1, 1989·Diagnostic Microbiology and Infectious Disease·K O Dugger, J N Galgiani

Related Concepts

Autoimmune Diseases
Blood Bactericidal Activity
Cell Adhesion
Chemotaxis, Leukocyte
Feedback - System Communication
Hematopoiesis, Medullary
Neutrophil Band Cells
Phagocytosis

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.