PMID: 6112779Mar 1, 1981Paper

The biological activity of catfish pancreatic somatostatin

Regulatory Peptides
H OyamaA Permutt

Abstract

Catfish pancreatic somatostatin, which contains eight additional amino acids on the amino terminus of a tetradecapeptide with considerable homology to tetradecapeptide somatostatin (SRIF), is a naturally occurring homolog of the hypothalamic peptide. The purpose of these studies was to determine the biological activity of this somatostatin homolog. Inhibition of 125I-labelled tyr1-SRIF binding to bovine pituitary plasma membranes by catfish pancreatic somatostatin was approximately 33% that of SRIF. Pancreatic somatostatin had full biological activity measured by inhibition of growth hormone release from isolated rat pituitary cells, but 0.01-0.1% the potency of SRIF. Pancreatic somatostatin at 100 ng/ml produced a 50-60% inhibition of insulin and glucagon secretion from perfused rat pancreas, while SRIF produced comparable inhibition at 10 ng/ml. This report demonstrates that a larger molecular form and natural homolog of SRIF, isolated from fish pancreas, has the same (but reduced) biological activities in rat assay systems as somatostatin originally isolated from sheep hypothalamus.

References

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May 1, 1980·The Journal of Clinical Investigation·H OyamaA Permutt
Sep 1, 1980·Endocrinology·H OyamaA Permutt

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Citations

May 1, 1982·Regulatory Peptides·H OyamaA Permutt
Jan 1, 1983·Regulatory Peptides·D J FletcherG C Weir
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M MagazinJ E Dixon
Feb 10, 2000·The Journal of Peptide Research : Official Journal of the American Peptide Society·L ChenG Barany
May 3, 2005·General and Comparative Endocrinology·Laura E Nelson, Mark A Sheridan
Oct 1, 1986·General and Comparative Endocrinology·M E AbadJ H Rombout
Aug 1, 1986·General and Comparative Endocrinology·E M PlisetskayaA Gorbman
Jan 1, 1986·Scandinavian Journal of Gastroenterology. Supplement·P C Andrews, J E Dixon

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