The Biological and Clinical Relevance of Inhibitor of Growth (ING) Genes in Non-Small Cell Lung Cancer

Cancers
Elisabeth SmolleMartin Pichler

Abstract

Carcinogenic mutations allow cells to escape governing mechanisms that commonly inhibit uncontrolled cell proliferation and maintain tightly regulated homeostasis between cell death and survival. Members of the inhibition of growth (ING) family act as tumor suppressors, governing cell cycle, apoptosis and cellular senescence. The molecular mechanism of action of ING genes, as well as their anchor points in pathways commonly linked to malignant transformation of cells, have been studied with respect to a variety of cancer specimens. This review of the current literature focuses specifically on the action mode of ING family members in lung cancer. We have summarized data from in vitro and in vivo studies, highlighting the effects of varying levels of ING expression in cancer cells. Based on the increasing insight into the function of these proteins, the use of ING family members as clinically useful biomarkers for lung cancer detection and prognosis will probably become routine in everyday clinical practice.

References

Feb 1, 1994·Current Opinion in Genetics & Development·P W Hinds, R A Weinberg
Nov 27, 1996·International Journal of Cancer. Journal International Du Cancer·A GemmaC C Harris
Jul 2, 2003·Journal of Clinical Pathology·G S NoumanB Angus
Feb 18, 2004·Molecular and Cellular Biology·Yannick DoyonJacques Côté
Mar 23, 2004·Journal of Molecular Biology·Anja RagvinRein Aasland
Nov 17, 2005·Cancer Research·Paul B Fisher
Mar 7, 2006·Experimental Cell Research·Michael RussellKarl Riabowol
Jun 10, 2008·Current Cancer Drug Targets·Mehmet GunduzHitoshi Nagatsuka
Dec 8, 2009·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Damien YthierRémy Pedeux
Feb 5, 2010·International Journal of Cancer. Journal International Du Cancer·Beyhan CengizHitoshi Nagatsuka
Feb 10, 2010·Chemistry & Biology·Karen T SmithJerry L Workman
Aug 14, 2010·Carcinogenesis·Alberto MorenoIgnacio Palmero
Sep 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suresh S RamalingamMerrill J Egorin
Jul 23, 2011·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jun LiuJianxing He
Jan 25, 2013·Nature Reviews. Cancer·Bram De Craene, Geert Berx
Dec 18, 2013·Cancer Letters·Claire GuérillonRémy Pedeux
Mar 19, 2014·FEBS Letters·Gesche Tallen, Karl Riabowol
May 31, 2014·Nature Cell Biology·Alain PuisieuxJulie Caramel
Aug 19, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·An YanLi Cai
Aug 22, 2016·Journal of Cancer Research and Clinical Oncology·Runyun ZhangYongzhong Hou
Apr 30, 2017·Oncology Letters·Wen-Feng GouHua-Chuan Zheng
May 24, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Verena StiegelbauerMartin Pichler
Aug 5, 2018·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nadine GantenbeinJohannes Haybaeck

❮ Previous
Next ❯

Citations

Aug 28, 2020·Frontiers in Immunology·Lia WalcherUta Kossatz-Boehlert

❮ Previous
Next ❯

Methods Mentioned

BETA
co-immunoprecipitation
transfection
xenograft
electron microscopy
gene array
FACS

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Current Drug Targets
Tatiana G Kutateladze
Cellular and Molecular Life Sciences : CMLS
E I CamposG Li
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Maryla KrajewskaJohn C Reed
Journal of Cancer Research and Clinical Oncology
Runyun ZhangYongzhong Hou
© 2021 Meta ULC. All rights reserved