The biological and toxicological activity of gases and vapors.

Toxicology in Vitro : an International Journal Published in Association with BIBRA
M H AbrahamW S Cain

Abstract

A large amount of data on the biological and toxicological activity of gases and vapors has been collected from the literature. Processes include sensory irritation thresholds, the Alarie mouse test, inhalation anesthesia, etc. It is shown that a single equation using only five descriptors (properties of the gases and vapors) plus a set of indicator variables for the given processes can correlate 643 biological and non-lethal toxicological activities of 'non-reactive' compounds with a standard deviation of 0.36 log unit. The equation is scaled to sensory irritation thresholds obtained by the procedure of Cometto-Muñiz, and Cain provides a general equation for the prediction of sensory irritation thresholds in man. It is suggested that differences in biological/toxicological activity arise primarily from transport from the gas phase to a receptor phase or area, except for odor detection thresholds where interaction with a receptor(s) is important.

References

Mar 1, 1986·Chemico-biological Interactions·D W Roberts
Nov 1, 1973·CRC Critical Reviews in Toxicology·Y Alarie
Oct 1, 1966·Archives of Environmental Health·Y Alarie
May 20, 1998·Archives of Toxicology·M H AbrahamW S Cain
Apr 9, 1999·Anesthesia and Analgesia·E I EgerT Hudlicky
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Jan 27, 2004·Journal of Chemical Information and Computer Sciences·Douglas M Hawkins
Jun 25, 2004·Journal of Chromatography. a·Michael H AbrahamAndreas M Zissimos
Aug 31, 2004·Anesthesia and Analgesia·Jason C Sewell, John W Sear
Jan 25, 2005·Indoor Air·J Enrique Cometto-MuñizMichael H Abraham
Sep 1, 2005·Toxicology and Applied Pharmacology·J Enrique Cometto-MuñizMichael H Abraham
Sep 6, 2005·Chemical Senses·J Enrique Cometto-MuñizMichael H Abraham
Mar 18, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·J Enrique Cometto-MuñizRicardo Sánchez-Moreno
Jun 23, 2006·Anesthesia and Analgesia·Albert WonJames M Sonner
Jun 30, 2006·Physiology & Behavior·William S CainMichael H Abraham
Sep 26, 2006·European Journal of Medicinal Chemistry·Michael H Abraham, Adam Ibrahim
Oct 3, 2006·The Science of the Total Environment·Kaci R BowenClara Rafols
Jan 24, 2007·Regulatory Toxicology and Pharmacology : RTP·Gunnar Damgård NielsenYves Alarie
Feb 27, 2007·Chemical Research in Toxicology·Jason W Yarbrough, T Wayne Schultz
May 16, 2007·Experimental Brain Research·J Enrique Cometto-MuñizRicardo Sánchez-Moreno
Sep 12, 2007·Journal of Pharmaceutical Sciences·Michael H AbrahamStacy Payne
Oct 6, 2007·Molecular Neurobiology·Bettina Malnic
Feb 6, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Yutaka TakahashiNaohiro Nishiyama
May 20, 2008·Toxicology and Applied Pharmacology·J Enrique Cometto-Muñiz, Michael H Abraham
Jul 8, 2008·European Journal of Medicinal Chemistry·Michael H Abraham, William E Acree
Jun 23, 2009·SAR and QSAR in Environmental Research·J C DeardenK L E Kaiser
Jan 1, 2009·New Journal of Chemistry = Nouveau Journal De Chimie·Michael H AbrahamJ Enrique Cometto-Muñiz
Jun 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M H AbrahamW S Cain
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M H AbrahamW S Cain

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Citations

Oct 12, 2010·Experimental Brain Research·J Enrique Cometto-Muñiz, Michael H Abraham
Mar 13, 2012·Journal of Chromatography. a·Thushara Karunasekara, Colin F Poole
Nov 10, 2015·Environment International·Michael H AbrahamJ Enrique Cometto-Muñiz
Feb 26, 2019·Journal of the Indian Society of Pedodontics and Preventive Dentistry·Nikita V Lolayekar, Sharmin S Kadkhodayan
Mar 29, 2014·Journal of Food and Drug Analysis·Haohao WuY Martin Lo
Aug 2, 2020·Analytical and Bioanalytical Chemistry·Alexandru Oprea, Udo Weimar
Jun 18, 2020·Journal of Exposure Science & Environmental Epidemiology·Matthew W LinakisJohn F Wambaugh

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