The biological characteristics of SARS-CoV-2 spike protein Pro330-Leu650

Vaccine
Qiu-Dong SuGui-Zhen Wu

Abstract

SARS-CoV-2 is the cause of the worldwide outbreak of COVID-19 that has been characterized as a pandemic by the WHO. Since the first report of COVID-19 on December 31, 2019, 179,111 cases were confirmed in 160 countries/regions with 7426 deaths as of March 17, 2020. However, there have been no vaccines approved in the world to date. In this study, we analyzed the biological characteristics of the SARS-CoV-2 Spike protein, Pro330-Leu650 (SARS-CoV-2-SPL), using biostatistical methods. SARS-CoV-2-SPL possesses a receptor-binding region (RBD) and important B (Ser438-Gln506, Thr553-Glu583, Gly404-Aps427, Thr345-Ala352, and Lys529-Lys535) and T (9 CD4 and 11 CD8 T cell antigenic determinants) cell epitopes. High homology in this region between SARS-CoV-2 and SARS-CoV amounted to 87.7%, after taking the biological similarity of the amino acids into account and eliminating the receptor-binding motif (RBM). The overall topology indicated that the complete structure of SARS-CoV-2-SPL was with RBM as the head, and RBD as the trunk and the tail region. SARS-CoV-2-SPL was found to have the potential to elicit effective B and T cell responses. Our findings may provide meaningful guidance for SARS-CoV-2 vaccine design.

Citations

Sep 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Muchtaridi MuchtaridiHabibah A Wahab
Jan 15, 2021·Chemical Communications : Chem Comm·Qingyu ZhaoXuanjun Wu
Jan 19, 2021·Journal of Basic Microbiology·Swapnil B KadamVitthal T Barvkar
Dec 3, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Jorge PulidoLuis A Rivas

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BETA
AAP41037.1

Software Mentioned

netMHCpan4
MODEL
DiscoTope
GraphPad Prism
MARIA
SWISS
DiscTope2

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