The biological characterization of neuroendocrine tumors: the role of neuroendocrine markers.

Journal of Endocrinological Investigation
P FerollaA Colao

Abstract

Neuroendocrine tumors (NET) may originate in different organs, from cells embryologically different but expressing common phenotypic characteristics, such as: the immuno-reactivity for markers of neuroendocrine differentiation (defined as "pan-neuroendocrine"), the capacity to secrete specific or aspecific peptide and hormones and the expression of some receptors, that are at the basis of the current diagnostic and therapeutical approach, peculiar to these tumors. NET have been conventionally distinguished in functioning, when associated with a recognized clinical endocrine syndrome, and non-functioning. However, this terminology may be misleading, since the great majority of NET may secrete neuroendocrine peptides, which can be employed as clinical markers for both diagnosis and follow-up. On the other hand, tissue immuno-reactivity for specific hormones does not always reflect secretory activity of the tumor cells. Finally, receptors and genetic markers are acquiring a relevant role in the characterization of NET, both improving knowledge of biology and physiopathology of NET, as well as in developing specific strategies to establish an early diagnosis and targeted therapies, to adopt prophylactic strategies in familial forms...Continue Reading

References

May 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A G Pearse
Jan 1, 1995·Virchows Archiv : an International Journal of Pathology·C CapellaG Klöppel
Mar 1, 1994·The Journal of Investigative Dermatology·I MollW W Franke
Apr 1, 1997·Microscopy Research and Technique·K A Seldeslagh, J M Lauweryns
Jul 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E T JansonK Oberg
May 20, 1998·The American Journal of Surgical Pathology·S X JiangH Yoshimura
Oct 29, 1998·British Journal of Cancer·E BaudinM Schlumberger
Dec 29, 1998·Human Pathology·E H HammondR L Flinner
Jan 30, 1999·The Journal of Pathology·G AbbonaG Bussolati
Aug 12, 1999·The Journal of Clinical Endocrinology and Metabolism·D GranbergB Skogseid
Aug 15, 2000·Digestion·A Calender
Aug 15, 2000·Digestion·B ErikssonM Stridsberg
Feb 24, 2001·European Journal of Gastroenterology & Hepatology·P TomassettiL Gullo
Oct 6, 2001·Frontiers in Neuroendocrinology·S W LambertsF R Nobels
Jan 5, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E BaudinM Schlumberger
Nov 28, 2002·Human Pathology·Susanne Van EedenMarie-Louise F Van Velthuysen
Dec 4, 2002·Clinical Endocrinology·Antongiulio FaggianoBernard Caillou
Mar 4, 2003·Human Pathology·Mary Beth BeasleyElizabeth Brambilla
May 13, 2003·The Journal of Endocrinology·M StridsbergE T Janson
Sep 20, 2005·The Journal of Medical Investigation : JMI·Nasim RayhanMitsuyoshi Hirokawa
Jan 10, 2006·The International Journal of Biological Markers·J SlodkowskaK Roszkowski-Sliz
Feb 2, 2006·Neuroendocrinology·Karin Birkenkamp-DemtröderTorben Falck Ørntoft
Mar 9, 2006·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M E PavelD Schuppan
Sep 7, 2006·Virchows Archiv : an International Journal of Pathology·Maode LaiQiong Huang

❮ Previous
Next ❯

Citations

Nov 1, 2013·European Journal of Endocrinology·Louise A LynggårdPeter Laurberg
Jun 17, 2014·Seminars in Pediatric Surgery·Paul R V Johnson
Feb 27, 2016·Critical Reviews in Oncology/hematology·Sara PuscedduMarina Chiara Garassino
Jul 18, 2014·PET Clinics·Anna Margherita MaffioneAbass Alavi
Jul 29, 2010·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Andrea FrillingUrsula Plöckinger
Jun 3, 2014·Journal of Experimental & Clinical Cancer Research : CR·Michela Del PreteUNKNOWN Multidisciplinary Group for NeuroEndocrine Tumors of Naples
Sep 27, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yuejuan ChengHongyan Ying
Jun 14, 2016·Case Reports in Oncological Medicine·Sapna Vinit AminShaila T Bhat
Oct 4, 2017·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Patricia MjønesHelge L Waldum
Mar 31, 2011·Nature Reviews. Endocrinology·Furio PaciniStefania Marchisotta
Feb 7, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Vincenzo MarottaAntongiulio Faggiano
May 17, 2013·Journal of Korean Medical Science·Woo Hyun PaikYong Bum Yoon
Jul 1, 2009·Expert Review of Endocrinology & Metabolism·Cornelis Jm LipsJo Wm Höppener
Sep 16, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Simona FerraroElia M Biganzoli
Jul 2, 2017·Journal of Endocrinological Investigation·M Del PreteUNKNOWN ENETS Centre of Excellence Multidisciplinary Group for Neuroendocrine Tumors in Naples (Italy)
Aug 15, 2017·Case Reports in Gastrointestinal Medicine·Jochen StenzelFlorian Eyer
Jan 19, 2019·Nature Communications·Haiyang GuoHousheng Hansen He
Sep 19, 2019·Journal of Clinical Medicine·Ralph A BundschuhMarkus Essler
Dec 13, 2018·Current Radiopharmaceuticals·Elisabetta GiovanniniAndrea Ciarmiello
Jun 29, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anna YordanovaHojjat Ahmadzadehfar
Jul 1, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Frontiers in Bioscience (Scholar Edition)
Massimiliano BerrettaVincenzo Canzonieri
Annals of Oncology : Official Journal of the European Society for Medical Oncology
P TomassettiR Corinaldesi
© 2022 Meta ULC. All rights reserved