PMID: 4909102Feb 1, 1970Paper

The biological false positive reaction to serological tests for syphilis

Journal of Clinical Pathology
M F Garner

Abstract

Acute and chronic biological false positive reactions to serological tests for syphilis are discussed. Three cases are presented, one showing an acute and one a chronic reaction, and one in which it was not possible to determine if the reaction was acute or chronic. Once a biological false positive reaction is found, serum from the patient should be tested at intervals for at least six months to determine if the reaction is acute or chronic. If a chronic reaction is found the patient should then be investigated to find the underlying cause. Problem sera from 753 patients are reviewed. Biological false positive reactions were shown by 47 sera and 257 sera gave results indicating they came from patients infected with syphilis. The reactive sera were divided into four groups: sera from blood donors, antenatal patients, cases of recent vaccination, and a miscellaneous group. It was found that in the first three groups the number of sera from patients showing biological false positive reactions was equalled or exceeded by the number showing syphilitic reactions. Biological false positive reactions in sera from cases of lepromatous leprosy and in sera from the inhabitants of the Okapa region of New Guinea are also discussed. It is co...Continue Reading

References

Nov 3, 1962·JAMA : the Journal of the American Medical Association·A M HARVEY
Oct 4, 1952·Journal of the American Medical Association·J E MOORE, C F MOHR

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Citations

Sep 1, 1970·Journal of Clinical Pathology·M F Garner, J L Backhouse
Nov 1, 1975·Journal of Clinical Pathology·R W Beal, D J Merry
Oct 1, 1974·The British Journal of Venereal Diseases·R E KaufmanP J Wiesner
Dec 1, 1982·The British Journal of Venereal Diseases·R NeyG Breguet
Oct 1, 1986·Genitourinary Medicine·A Hossain
Dec 3, 2014·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Nobuyasu YukimasaKunihiko Fukuchi
Jul 1, 2006·Vision Research·Denis G PelliDeborah C Moore-Page
Jun 25, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Susan TuddenhamKhalil G Ghanem
Apr 1, 1982·Tropical Doctor·E F OmerI A Khalil
Jun 1, 1973·Bacteriological Reviews·K W Knox, A J Wicken
Jun 1, 1972·Infection and Immunity·A J WickenK W Knox

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