The biological function and the regulatory roles of wild-type p53-induced phosphatase 1 in immune system.

International Reviews of Immunology
Lu ShiYong Zhao

Abstract

Wild-type p53-induced phosphatase 1 (WIP1) belongs to the protein phosphatase 2C (PP2C) family and is a mammalian serine/threonine specific protein phosphatase to dephosphorylate numerous signaling molecules. Mammalian WIP1 regulates a wide array of targeting molecules and plays key regulatory roles in many cell processes such as DNA damage and repair, cell proliferation, differentiation, apoptosis, and senescence. WIP1 promotes the formation and development of tumors as an oncogene and a negative regulator of p53. It is also involved in the regulation of aging, neurological diseases and immune diseases. Recent studies demonstrated the critical roles of WIP1 in the differentiation and function of immune cells including T cells, neutrophils and macrophages. In the present manuscript, we briefly summarized the expression patterns, biological function and the target molecules and signal pathways of WIP1 and mainly discussed the latest advances on the regulatory effects of WIP1 in the immune system. WIP1 may be a potential target molecule to treat cancers and immune diseases such as allergic asthma.

References

Jan 1, 1989·Annual Review of Biochemistry·P Cohen
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·M FiscellaE Appella
May 22, 2002·Nature Genetics·Dmitry V BulavinEttore Appella
Nov 29, 2005·Cell Death and Differentiation·H FujimotoY Minami
Apr 6, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marco L SchitoEttore Appella
Sep 5, 2006·Molecular Cell·Sathyavageeswaran ShreeramDmitry V Bulavin
Feb 13, 2008·Cancer Metastasis Reviews·Xiongbin LuLawrence A Donehower
Apr 21, 2009·Nature Cell Biology·Joanne ChewVinay Tergaonkar
Feb 2, 2010·The Journal of Biological Chemistry·Sung-Hwan MoonLawrence A Donehower
May 11, 2010·DNA Repair·Thuy-Ai NguyenLawrence A Donehower
May 13, 2010·Cancer Research·Hyukjin ChaAlbert J Fornace
Dec 29, 2011·Frontiers in Bioscience (Landmark Edition)·Julie LoweAlbert J Fornace
Jul 10, 2012·Cell Metabolism·Xavier Le GuezennecDmitry V Bulavin
Aug 21, 2013·Journal of Molecular Neuroscience : MN·Xiang TanYongjin Pan
Aug 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lina SunYong Zhao
Jan 7, 2014·Nature Chemical Biology·Aidan G GilmartinRakesh Kumar
Jan 8, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bo SunYong Zhao
Jun 24, 2014·Bioorganic & Medicinal Chemistry Letters·Matthew D CheesemanKeith Jones
Nov 11, 2014·Expert Review of Clinical Immunology·Xiaofei ShenWenxian Guan
Feb 24, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lingling ZhangZhenyu Ju
Dec 31, 2015·Apoptosis : an International Journal on Programmed Cell Death·Bo WuKai-Xing Ai
Feb 18, 2016·Oncotarget·Anastasia R GoloudinaOleg N Demidov
Mar 8, 2016·Inflammatory Bowel Diseases·Xuelian HuYong Zhao
May 18, 2016·Oncotarget·Anusha SriramanMatthias Dobbelstein
May 22, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Haibin ZhongMin Li

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Citations

Apr 23, 2021·Cell Communication and Signaling : CCS·Clovis H T SeumenChristof R Hauck

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