Abstract
The reliable detection of circulating tumor cells (CTCs) in metastatic breast cancer (MBC) is possible by using immunomagnetic separation and subsequent characterization with the CellSpotter analyzer (Veridex LLC, a Johnson & Johnson company, Warren, NJ, USA). This technology is becoming a standard tool for the 'real-time' assessment of prognosis and response to treatment. The prognostic value is independent of the line of therapy (e.g. first-line versus second-line or more), site of metastasis (e.g. visceral versus soft tissue/bone), and subtype of disease (e.g. basal vs. luminal). Moreover, CTCs detection has been recently associated with worse outcome also in patients with primary breast cancer that have completed neoadjuvant or adjuvant therapy. These findings suggest the need to further investigate the biology of CTCs. Several investigators have recently focused on determining the feasibility of performing the genotypic characterization of CTCs and correlate it with the expression of similar genes in primary or metastatic lesions. Some of the studies have used a recently introduced detection technology combining EpCAM-enrichment and PCR analysis (AdnaTest Breast Cancer, Adnagen AG, Germany). The studies seem to indicate th...Continue Reading
References
Nov 18, 1971·The New England Journal of Medicine·J Folkman
Jan 17, 1995·Proceedings of the National Academy of Sciences of the United States of America·H J GrossD Recktenwald
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·E RacilaJ W Uhr
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·K J MartinA B Pardee
Oct 17, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·K PachmannG Tilz
Jun 29, 2002·Cancer Detection and Prevention·Patrizia BossolascoGiorgio Lambertenghi Deliliers
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Mar 1, 1958·A.M.A. Archives of Surgery·S ROBERTSW H COLE
Jun 1, 1960·Archives of Surgery·L LONGW H COLE
Oct 3, 2003·Cell Proliferation·Gabriela DontuMax S Wicha
Apr 28, 2004·Current Opinion in Genetics & Development·Muhammad Al-HajjMichael F Clarke
Jun 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Songdong MengJonathan Uhr
Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo CristofanilliLeon W M M Terstappen
Mar 3, 2005·Journal of Pharmaceutical and Biomedical Analysis·Weiyong LiTridarsh Shah
Sep 1, 2006·Molecular Biotechnology·Silke LankiewiczOliver Bócher
Nov 3, 2006·Proceedings of the National Academy of Sciences of the United States of America·Songdong MengJonathan Uhr
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine RiethdorfKlaus Pantel
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michail IgnatiadisDimitris Mavroudis
Aug 6, 2008·Breast Cancer Research and Treatment·Mitra TewesSabine Kasimir-Bauer
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Yves PiergaMichel Marty
Citations
Jan 14, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ningfang WangXincai Qu
Aug 6, 2011·Breast Cancer Research : BCR·Siri TveitoØystein Fodstad
Jul 20, 2012·PloS One·Jorge BarbazánMiguel Abal
Jan 10, 2014·Biomicrofluidics·Sangjo ShimPeter R C Gascoyne
Jun 4, 2010·Journal of Mammary Gland Biology and Neoplasia·Tony BlickErik W Thompson
Nov 21, 2019·The Analyst·Yun ZhouDimitri Pappas
Jun 18, 2011·Journal of Cancer Research and Clinical Oncology·Yun-Fan SunYang Xu
Feb 6, 2016·Oncology Reports·Ulrich AndergassenUdo Jeschke
Oct 4, 2016·Breast Cancer Research and Treatment·Thomas M DeutschMarkus Wallwiener
Jul 11, 2020·International Journal of Molecular Sciences·Stefano GuadagniAndrew Reay Mackay
May 22, 2020·Breast Cancer Research and Treatment·Thomas M DeutschMarkus Wallwiener
May 1, 2011·Experimental and Therapeutic Medicine·Chuanli RenHongbing Shen
Apr 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anieta M SieuwertsJohn W M Martens
Sep 14, 2021·Current Reviews in Clinical and Experimental Pharmacology·Da-Yong Lu, Ting-Ren Lu