The biological information obtainable from circulating tumor cells

The Breast : Official Journal of the European Society of Mastology
Massimo Cristofanilli

Abstract

The reliable detection of circulating tumor cells (CTCs) in metastatic breast cancer (MBC) is possible by using immunomagnetic separation and subsequent characterization with the CellSpotter analyzer (Veridex LLC, a Johnson & Johnson company, Warren, NJ, USA). This technology is becoming a standard tool for the 'real-time' assessment of prognosis and response to treatment. The prognostic value is independent of the line of therapy (e.g. first-line versus second-line or more), site of metastasis (e.g. visceral versus soft tissue/bone), and subtype of disease (e.g. basal vs. luminal). Moreover, CTCs detection has been recently associated with worse outcome also in patients with primary breast cancer that have completed neoadjuvant or adjuvant therapy. These findings suggest the need to further investigate the biology of CTCs. Several investigators have recently focused on determining the feasibility of performing the genotypic characterization of CTCs and correlate it with the expression of similar genes in primary or metastatic lesions. Some of the studies have used a recently introduced detection technology combining EpCAM-enrichment and PCR analysis (AdnaTest Breast Cancer, Adnagen AG, Germany). The studies seem to indicate th...Continue Reading

Associated Clinical Trials

Sep 5, 2013·AKANIST PIYAPANT, MD.,FRCST.
Sep 16, 2013·AKANIST PIYAPANT, MD.,FRCST.

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Citations

Jan 14, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ningfang WangXincai Qu
Jun 18, 2011·Journal of Cancer Research and Clinical Oncology·Yun-Fan SunYang Xu
Oct 4, 2016·Breast Cancer Research and Treatment·Thomas M DeutschMarkus Wallwiener
May 22, 2020·Breast Cancer Research and Treatment·Thomas M DeutschMarkus Wallwiener
May 1, 2011·Experimental and Therapeutic Medicine·Chuanli RenHongbing Shen
Apr 21, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anieta M SieuwertsJohn W M Martens
Sep 14, 2021·Current Reviews in Clinical and Experimental Pharmacology·Da-Yong Lu, Ting-Ren Lu

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