PMID: 14412201Jan 1, 1960Paper

The biological mechanisms of air ion action. I. 5-Hydroxytryptamine as the endogenous mediator of positive air ion effects on the mammalian trachea

The Journal of General Physiology
A P Krueger, R F SMITH

Abstract

Intravenous administration of 5-hydroxytryptamine to rabbits and guinea pigs is shown to bring about changes very similar to those produced by (+) air ions, including (1) decreased ciliary rate, (2) contraction of the posterior tracheal wall, (3) exaggerated response of the tracheal mucosa to trauma, (4) marked vasoconstriction in the tracheal wall, and (5) increased respiratory rate. These effects are reversed by (-) air ions. Iproniazid, which raises 5-hydroxytryptamine levels in the animal by blocking monamine oxidase, produces similar but non-reversible effects. Reserpine, which depletes 5-hydroxytryptamine in the animal, causes changes that resemble those produced by (-) air ions, including (1) increased ciliary rate, (2) relaxed posterior sulcus, (3) hyperemia of the tracheal mucosa, (4) lowered respiratory rate, and (5) increased volume and rate of mucus flow. On the basis of these facts, the hypothesis is advanced that (+) air ion effects are mediated by the release of free 5-hydroxytryptamine, while (-) air ion effects depend on the ability of (-) ions to accelerate the enzymatic oxidation of 5-hydroxytryptamine.

References

Mar 14, 1957·Annals of the New York Academy of Sciences·S UDENFRIENDD F BOGDANSKI
Dec 1, 1957·Proceedings of the Society for Experimental Biology and Medicine·A P KRUEGER, R F SMITH
Jul 1, 1959·Proceedings of the Society for Experimental Biology and Medicine·A P KRUEGERJ W MILLAR

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Citations

Jun 1, 1988·International Journal of Biometeorology·L L Morton
May 1, 1990·International Journal of Biometeorology·L L Morton, J R Kershner
Mar 1, 1974·International Journal of Biometeorology·A P KruegerK A Brook
Oct 1, 1969·International Journal of Biometeorology·R S Pogrund
Dec 1, 1968·International Journal of Biometeorology·T Csato
Aug 1, 1972·International Journal of Biometeorology·A P Krueger, E J Reed
Sep 1, 1970·International Journal of Biometeorology·A P KruegerS Turner
Mar 15, 1976·Experientia·E TalF G Sulman
Dec 1, 1981·International Journal of Biometeorology·S M HinsullE L Head
Jun 1, 1969·International Journal of Biometeorology·A P Krueger, S Kotaka
Jan 1, 1976·Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology·J Iravani, G N Melville
Sep 8, 1962·Nature·W C LEVENGOOD, M P SHINKLE
Nov 1, 1962·The Journal of General Physiology·R E GOSSELINA S MILTON
Aug 1, 1982·Biological Reviews of the Cambridge Philosophical Society·G Clough
Jan 1, 1978·CRC Critical Reviews in Microbiology·S Kotaka
Jan 1, 1961·IRE Transactions on Bio-medical Electronics·A H FREY
Jan 1, 1986·International Journal of Psychiatry in Medicine·A J GianniniW A Price
Dec 1, 1963·Archives of Environmental Health·N LEFCOE
Aug 1, 1961·Journal of Cellular and Comparative Physiology·R E GOSSELIN
Mar 1, 1978·International Journal of Biometeorology· Bhartendu, I A Menon
Jun 1, 1987·Journal of Mental Deficiency Research·L L Morton, J R Kershner
Sep 30, 1966·Annals of the New York Academy of Sciences·S CarsonM S Weinberg
May 1, 1961·Archives of Environmental Health·M Y LONGLEY, C M BERRY
Sep 1, 1973·International Journal of Biometeorology·J M Olivereau
Jun 6, 2018·Biomedical Engineering Online·William H BaileyMegan Jeanne Leonhard

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