The biological revolution - towards a mechanistic understanding of the impact of diet on cancer risk

Mutation Research
John C Mathers

Abstract

There is strong epidemiological evidence to show that differences in diet explain a significant proportion of the variation in cancer incidence worldwide. However, because of the complex nature of eating behaviour and the chemical heterogeneity of foods, it remains very difficult to ascertain which aspects of diet, in what quantities and over what time-frames are responsible for modifying risk. In addition, there are few dietary intervention studies demonstrating reduction in cancer risk. Much faster progress has been made in understanding the biological basis of cancer. It is now clear that damage to the genome resulting in aberrant expression of genes (principally suppression of tumour suppressor genes (TSGs) and inappropriate expression of oncogenes) is fundamental to tumorigenesis. It is also becoming clear that much of the inter-individual variation in cancer experience is due to differences in the amount of damage experienced and/or the capacity to repair that damage. Both of these processes are influenced strongly by dietary factors and by genetic predisposition (polymorphisms in the requisite genes). It is possible that understanding diet:gene interactions in DNA damage and in repair will not only explain much of the in...Continue Reading

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Citations

Apr 4, 2008·Cancer Causes & Control : CCC·Brian C-H ChiuDennis D Weisenburger
Oct 14, 2008·Genes & Nutrition·J C Mathers
Jul 14, 2005·Annual Review of Nutrition·Douglas M RudenXiangyi Lu
Oct 14, 2008·Genes & Nutrition·Christine M WilliamsBen van Ommen
May 5, 2006·The Proceedings of the Nutrition Society·John C Mathers
Jul 1, 2004·Mutation Research·Andrew R Collins, Lynnette R Ferguson
Jun 22, 2016·Cyberpsychology, Behavior and Social Networking·Jorge OsmaEleni Ramphos
Mar 21, 2012·Traffic Injury Prevention·P PuvanachandraA A Hyder
Jun 16, 2012·Ciência & saúde coletiva·Gregg Lawrence Furie, John Balbus
May 13, 2006·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Farid E Ahmed
Dec 10, 2008·Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Diététique : Une Publication Des Diététistes Du Canada·Milly Ryan-HarshmanKristin Anderson
Dec 1, 2005·The Journal of Nutrition·Laura BasterfieldJohn C Mathers

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