The biology and diagnostic applications of plasma RNA

Annals of the New York Academy of Sciences
Y M Dennis Lo, Rossa W K Chiu

Abstract

The detection of cell-free RNA in the plasma and serum of human subjects has opened up new investigational opportunities. Tumor-derived RNA was detected in the plasma and serum of patients with various forms of cancer. Through the development of robust extraction and quantification protocols for circulating RNA, new information regarding its biology and characteristics has been obtained. Plasma RNA was shown to be particle associated and to be surprisingly stable. Recently, fetal RNA was also demonstrated in maternal plasma. The placenta was shown to be an important source of such circulating fetal RNA. This discovery has created new prenatal diagnostic and monitoring possibilities. It is expected that circulating RNA will find application in many other clinical scenarios, including emergency medicine.

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Citations

May 13, 2014·Journal of Reproductive Immunology·Sinuhe HahnPaul Hasler
Sep 21, 2006·Neoplasia : an International Journal for Oncology Research·Siu Tim CheungSheung Tat Fan
Jun 2, 2012·International Journal of Hepatology·Tara Behne, M Sitki Copur
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Oct 8, 2008·Annals of the New York Academy of Sciences·S AgalouR Swaminathan
May 21, 2010·American Journal of Reproductive Immunology : AJRI·Ekaterine TskitishviliTadashi Kimura
Dec 9, 2004·Biochimica Et Biophysica Acta·Jeff CummingsCaroline Dive
Aug 17, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Gyorgy Csako
Mar 25, 2005·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S IllanesP W Soothill
Oct 17, 2009·Clinical Chemistry·Rebecca W Y ChanRossa W K Chiu
Apr 28, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Blenda C K WongY M Dennis Lo

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