The biology and management of uveal melanoma.

Current Oncology Reports
Takami SatoAkira Yamamoto

Abstract

Uveal melanoma is the most common primary intraocular malignancy in adults. Overall mortality rate remains high because of the frequent development of metastatic disease, especially hepatic metastasis. While traditional systemic chemotherapies provide only marginal benefit to patients, local treatments for hepatic metastases, such as immunoembolization, have improved patient prognoses. Progress has also been made in identifying potential targets in the pathways involved in apoptosis, proliferation, invasion, metastasis, and angiogenesis of uveal melanoma. Among these pathways, the c-Kit, c-Met, and IGF-1R signal pathways and the PTEN-related PI3K-Akt pathway are the most important targets. Clinical trials using blockades of these pathways in conjunction with strategies to facilitate apoptosis is a direction for future clinical trials. Application of these approaches in the adjuvant setting after primary therapy for high-risk uveal melanoma patients is also a future consideration to improve the clinical outcome of this disease.

References

Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·P G NataliA Ullrich
Mar 1, 1991·Ophthalmology·E S GragoudasM D Spar
May 1, 1988·Cancer Genetics and Cytogenetics·C A GriffinA P Schachat
Aug 19, 1988·JAMA : the Journal of the American Medical Association·G M MavligitS Wallace
May 4, 1996·Lancet·G PrescherR Becher
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S LeyvrazL Zografos
Nov 20, 1997·Journal of Cellular Physiology·M Bar-Eli
Apr 21, 1999·The British Journal of Ophthalmology·J S ChanaJ L Hungerford
Jul 12, 2001·Experimental Eye Research·F MouriauxP Labalette
Jul 27, 2001·Melanoma Research·A D SinghJ A Shields
Jun 18, 2002·Nature·Helen DaviesP Andrew Futreal
Apr 12, 2003·Melanoma Research·Frédéric MouriauxSimon Saule
Sep 27, 2003·Virchows Archiv : an International Journal of Pathology·Mona PachePeter Meyer
Oct 24, 2003·Familial Cancer·Femke A de SnooNelleke A Gruis
Oct 28, 2003·Investigative Ophthalmology & Visual Science·Emma KujalaTero Kivelä
Nov 18, 2003·International Journal of Cancer. Journal International Du Cancer·Mattias HöglundDouglas Horsman
May 1, 2004·Current Opinion in Ophthalmology·Carol L Shields, Jerry A Shields
May 18, 2004·The Journal of Biological Chemistry·Gaëlle LefevreFrédéric Mascarelli
Mar 15, 2005·Ophthalmology Clinics of North America·Arun D SinghStefan Seregard
Jul 22, 2005·Melanoma Research·Vinicius S SaraivaMiguel N Burnier
Nov 24, 2005·Investigative Ophthalmology & Visual Science·Mario A EconomouStefan Seregard
Dec 14, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mohamed H Abdel-RahmanCharis Eng
Dec 21, 2005·International Ophthalmology Clinics·Agop Y Bedikian
Feb 10, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Courtney A GranvillePhillip A Dennis
Feb 21, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ada GirnitaLeonard Girnita
May 3, 2006·Cancer Research·Michael D OnkenJ William Harbour
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Benedetta Peruzzi, Donald P Bottaro
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Vaqar Mustafa AdhamiHasan Mukhtar
Dec 13, 2006·The Journal of Investigative Dermatology·Wendy LiuGrant A McArthur
Nov 10, 2007·Melanoma Research·Wieke ZuidervaartNicholas K Hayward
Oct 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Takami SatoKevin L Sullivan

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Citations

Jun 25, 2013·Clinical & Experimental Metastasis·John M LattierHans E Grossniklaus
Oct 15, 2013·Current Oncology Reports·Sapna P Patel
Sep 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Deborah C Otteson
Feb 20, 2013·The Journal of Experimental Medicine·Rubeta N MatinDaniele Bergamaschi
Jan 29, 2014·La Radiologia medica·Tommaso TartaglioneCesare Colosimo
Nov 29, 2015·The American Journal of Pathology·Shinji OzakiTakami Sato
Mar 29, 2011·Journal français d'ophtalmologie·N Abi-AyadJ Couturier
Dec 10, 2013·Journal of Cellular Physiology·Biao YanQin Jiang
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Yi-Rui GeZheng-Ping Huang
May 31, 2019·Cancers·Leanne de KoningFariba Némati
May 14, 2009·Seminars in Ophthalmology·Pooja BhatRobert Folberg
Feb 1, 2019·Cancers·Eric FountainSapna P Patel
Oct 1, 2020·Cancers·Fabiana MalloneAntonietta Moramarco
Jun 29, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristof HardaGabor Halmos
Jun 1, 2016·Melanoma Management·Dae Won KimSapna P Patel
Nov 21, 2012·Melanoma Research·Matias E ValsecchiTakami Sato

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