The biology and mechanism of action of suppressor of cytokine signaling 3.

Growth Factors
Jeffrey J Babon, Nicos A Nicola

Abstract

Suppressors of cytokine signaling 3 (SOCS3) has been shown to be an important and non-redundant feedback inhibitor of several cytokines including leukemia inhibitory factor, IL-6, IL-11, Ciliary neurotrophic factor (CNTF), leptin, and granulocyte colony-stimulating factor (G-CSF). Loss of SOCS3 in vivo has profound effects on placental development, inflammation, fat-induced weight gain, and insulin sensitivity. SOCS3 expression is induced by Janus kinase (JAK)/signal transducers and activators of transcription (STAT) signaling and it then binds to specific cytokine receptors (including gp130, G-CSF, and leptin receptors). SOCS3 then inhibits JAK/STAT signaling in two distinct ways. First, SOCS3 is able to directly inhibit the catalytic activity of JAK1, JAK2, or TYK2 while remaining bound to the cytokine receptor. Second, SOCS3 recruits elongins B/C and Cullin5 to generate an E3 ligase that ubiquitinates both JAK and cytokine receptor targeting them for proteasomal degradation. Detailed in vivo studies have revealed that SOCS3 action not only limits the duration of cytokine signaling to prevent overactivity but it is also important in maintaining the specificity of cytokine signaling.

References

Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·J E LadburyJ Schlessinger
May 1, 1994·Trends in Biochemical Sciences·J N IhleO Silvennoinen
Jun 26, 1997·Nature·R StarrD J Hilton
Feb 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·D J HiltonN A Nicola
Dec 10, 1999·The Journal of Biological Chemistry·P A Ram, D J Waxman
Jun 1, 2000·Proceedings of the National Academy of Sciences of the United States of America·S E NicholsonM Baca
Oct 6, 2000·The Journal of Biological Chemistry·C BjorbakM G Myers
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·A W RobertsW S Alexander
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·J G ZhangN A Nicola
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Charles E EgwuaguIgal Gery
Apr 19, 2002·Nature·Ning ZhengNikola P Pavletich
May 25, 2002·European Journal of Biochemistry·Michael HörtnerSerge Haan
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michael HörtnerSerge Haan
Sep 5, 2002·The Journal of Biological Chemistry·Christopher J GreenhalghDouglas J Hilton
Feb 20, 2003·The Journal of Experimental Medicine·Akira MatsumotoMasato Kubo
May 20, 2003·Nature Immunology·Ben A CrokerWarren S Alexander
May 20, 2003·Nature Immunology·Roland LangPeter J Murray
May 20, 2003·Nature Immunology·Hideo YasukawaAkihiko Yoshimura
Jul 9, 2003·Nature Medicine·Yoh-ichi SekiMasato Kubo
Dec 14, 2004·The Journal of Biological Chemistry·Edith KarioYosef Yarden
Feb 8, 2005·Proceedings of the National Academy of Sciences of the United States of America·Sandra E NicholsonNicos A Nicola

❮ Previous
Next ❯

Citations

Mar 13, 2014·Seminars in Immunology·Qing ChangJacqueline Bromberg
Feb 13, 2016·Molecular and Cellular Endocrinology·M van de VyverW F Ferris
Jan 7, 2015·Cellular Signalling·Christian EhltingJohannes G Bode
Dec 10, 2013·Neuroscience·V S NagaishiJ Donato
Apr 7, 2015·Clinical Oral Investigations·Denise C AndiaAna P de Souza
Apr 23, 2015·Asia-Pacific Journal of Clinical Oncology·Xian FuJiaquan Xiao
Jul 19, 2013·Biochemical Society Transactions·Nadia J KershawJeffrey J Babon
Jul 25, 2014·The Biochemical Journal·Jeffrey J BabonLeila N Varghese
Jan 29, 2014·JAK-STAT·Yong Tang, Xiuchun Cindy Tian
Dec 3, 2014·Seminars in Immunology·Martin E Rottenberg, Berit Carow
Nov 18, 2014·Frontiers in Immunology·Amitabha Chaudhuri
May 4, 2016·Cellular and Molecular Life Sciences : CMLS·R MahonyN J Stevenson
Jun 20, 2016·Atherosclerosis·Vivianne B C KokjeJan H N Lindeman
Aug 27, 2016·Epigenetics : Official Journal of the DNA Methylation Society·Omar AliYi Zhang
Sep 23, 2016·International Journal of Molecular Sciences·Atsuko KimuraTakayuki Harada
Jul 9, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lu-Sha TongJohn H Zhang
Mar 16, 2017·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·T GuiC Yang
Apr 19, 2017·FEBS Letters·Snahlata SinghManoj Kumar Bhat
Oct 16, 2018·Growth Factors·Edmond M LinossiSandra E Nicholson
Oct 5, 2017·PLoS Genetics·Yuting QinNan Shen
Sep 30, 2018·Protein Science : a Publication of the Protein Society·Rhiannon MorrisJeffrey J Babon
Sep 21, 2013·Journal of Applied Physiology·Tara L MacdonaldDavid C Wright
Apr 16, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Chunguang YanHongwei Gao
Dec 31, 2019·Current Drug Targets·Adele SoltaniAbdolamir Allameh
Sep 2, 2020·International Journal of Molecular Sciences·Ismael KhoulyFarah Asa'ad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.