The biology of human overfeeding: A systematic review.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
George A Bray, C Bouchard

Abstract

This systematic review has examined more than 300 original papers dealing with the biology of overfeeding. Studies have varied from 1 day to 6 months. Overfeeding produced weight gain in adolescents, adult men and women and in older men. In longer term studies, there was a clear and highly significant relationship between energy ingested and weight gain and fat storage with limited individual differences. There is some evidence for a contribution of a genetic component to this response variability. The response to overfeeding was affected by the baseline state of the groups being compared: those with insulin resistance versus insulin sensitivity; those prone to obesity versus those resistant to obesity; and those with metabolically abnormal obesity versus those with metabolically normal obesity. Dietary components, such as total fat, polyunsaturated fat and carbohydrate influenced the patterns of adipose tissue distribution as did the history of low or normal birth weight. Overfeeding affected the endocrine system with increased circulating concentrations of insulin and triiodothyronine frequently present. Growth hormone, in contrast, was rapidly suppressed. Changes in plasma lipids were influenced by diet, exercise and the mag...Continue Reading

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Citations

Feb 3, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·R James Stubbs, Jake Turicchi
Apr 25, 2021·European Journal of Clinical Nutrition·Harshpal Singh SachdevAnura V Kurpad
Apr 20, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Jean-Philippe WalhinJames A Betts
Jun 17, 2021·The American Journal of Clinical Nutrition·Manfred J MüllerAnja Bosy-Westphal
Jul 22, 2021·Nature Reviews. Molecular Cell Biology·David E JamesMorris J Birnbaum
Jul 23, 2021·The Journal of Nutrition·Elaine A YuAryeh D Stein
Aug 6, 2021·Current Opinion in Endocrinology, Diabetes, and Obesity·Sam Feltham, Eric C Westman

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