The biology of kinetoplastid parasites: insights and challenges from genomics and post-genomics

International Journal for Parasitology
K Gull

Abstract

Kinetoplastid parasites exhibit a rich and diverse biology which mirrors many of the most interesting topics of current interest and study in the broader biological sciences. These evolutionarily ancient organisms possess intriguing mechanisms for control of gene expression, and exhibit complex patterns of cell morphogenesis orchestrated by an internal cytoskeleton. Their cell shapes change during a set of complex cell type differentiations in their life cycles. These differentiations are intimately linked to interactions with mammalian hosts or insect vectors, and often, these differentiations appear central to the successful transfer of the parasite between vector and host, and host and vector. The basics of this rich and complex cell and life cycle biology were described (with often rather forgotten clarity and prescience) in the early period of the last century. The last 30 years have seen major developments in our understanding of this biology. Ultrastructural differences in the various cells of the life cycle stages of Trypanosoma brucei, Trypanosoma cruzi and the various Leishmania species have been documented, and such studies have proven highly informative in defining important aspects of parasite adaptation. They have...Continue Reading

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Citations

Mar 17, 2004·Biochimica Et Biophysica Acta·Christian Doerig
Apr 14, 2005·International Journal for Parasitology·Ross L Coppel, Casilda G Black
Dec 10, 2003·Current Opinion in Microbiology·Paul G McKean
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Aug 15, 2012·FEMS Microbiology Letters·Anup Kumar Maity, Partha Saha
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Feb 7, 2021·International Journal of Biological Macromolecules·Edna Gicela Ortiz MoreaMaria Isabel Nogueira Cano

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