The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications

Endocrine Reviews
Teresa M SecciaG P Rossi

Abstract

The identification of several germline and somatic ion channel mutations in aldosterone-producing adenomas (APAs) and detection of cell clusters that can be responsible for excess aldosterone production, as well as the isolation of autoantibodies activating the angiotensin II type 1 receptor, have rapidly advanced the understanding of the biology of primary aldosteronism (PA), particularly that of APA. Hence, the main purpose of this review is to discuss how discoveries of the last decade could affect histopathology analysis and clinical practice. The structural remodeling through development and aging of the human adrenal cortex, particularly of the zona glomerulosa, and the complex regulation of aldosterone, with emphasis on the concepts of zonation and channelopathies, will be addressed. Finally, the diagnostic workup for PA and its subtyping to optimize treatment are reviewed.

Associated Clinical Trials

Dec 4, 2019·Gian Paolo Rossi, MD, FAHA, FACC

Citations

Mar 3, 2020·Hypertension·Celso E Gomez-SanchezKenji Oki
Oct 31, 2019·The Journal of Clinical Endocrinology and Metabolism·Gian Paolo Rossi
Feb 19, 2020·The Journal of Clinical Endocrinology and Metabolism·Gian Paolo RossiTeresa Maria Seccia
Aug 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Samuel Matthew O'TooleWilliam Martyn Drake
Aug 28, 2020·The Journal of Clinical Endocrinology and Metabolism·Guido Di DalmaziFrancesco Fallo
Sep 25, 2020·Endocrine Journal·Kenji Oki, Celso E Gomez-Sanchez
Oct 24, 2020·Physiological Research·M HillI Sterzl
May 20, 2021·Scientific Reports·Ravi Kumar DuttaPeter Söderkvist
May 21, 2021·The Tohoku Journal of Experimental Medicine·Xin GaoHironobu Sasano
Jun 3, 2021·International Journal of Molecular Sciences·Margaux LaulhéLaetitia Martinerie

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