The biology of zinc transport in mammary epithelial cells: implications for mammary gland development, lactation, and involution

Journal of Mammary Gland Biology and Neoplasia
Nicholas H McCormickShannon L Kelleher

Abstract

Zinc plays a critical role in a vast array of cellular functions including gene transcription, protein translation, cell proliferation, differentiation, bioenergetics, and programmed cell death. The mammary gland depends upon tight coordination of these processes during development and reproduction for optimal expansion, differentiation, and involution. For example, zinc is required for activation of matrix metalloproteinases, intracellular signaling cascades such as MAPK and PKC, and the activation of both mitochondrial-mediated apoptosis and lysosomal-mediated cell death. In addition to functional needs, during lactation the mammary gland must balance providing optimal zinc for cellular requirements with the need to secrete a substantial amount of zinc into milk to meet the requirements of the developing neonate. Finally, the mammary gland exhibits the most profound example of programmed cell death, which is driven by both apoptotic and lysosomal-mediated cell death. Two families of zinc-specific transporters regulate zinc delivery for these diverse functions. Members of the ZIP family of zinc transporters (ZIP1-14) import zinc into the cytoplasm from outside the cell or from subcellular organelles, while members of the ZnT f...Continue Reading

References

Feb 1, 1991·Experimental Cell Research·J K Chesters, R Boyne
Oct 1, 1989·Experimental Cell Research·J K ChestersH Vint
Jun 1, 1970·Experimental Cell Research·H J Helminen, J L Ericsson
May 1, 1982·The American Journal of Clinical Nutrition·G Harzer, H Kauer
Dec 1, 1982·The American Journal of Clinical Nutrition·B LönnerdalL S Hurley
Jan 1, 1980·Journal of Inorganic Biochemistry·B LönnerdalL S Hurley
Jan 1, 1993·Physiological Reviews·B L Vallee, K H Falchuk
May 1, 1997·Digestive Diseases and Sciences·S ParkkilaH Rajaniemi
Nov 5, 1997·The Journal of Biological Chemistry·H R Stennicke, G S Salvesen
Oct 24, 1998·Biochemical and Biophysical Research Communications·B J ThatcherR I Henkin
Feb 22, 2000·The Journal of Biological Chemistry·L A Gaither, D J Eide
Aug 23, 2000·The Journal of Biological Chemistry·S J LangmadeG K Andrews
Apr 13, 2001·The Journal of Biological Chemistry·L A Gaither, D J Eide
Sep 7, 2001·Current Opinion in Cell Biology·L J McCawley, L M Matrisian
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·P KarhumaaH Rajaniemi
Feb 8, 2002·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·A Q Truong-TranP D Zalewski
Apr 9, 2002·The Journal of Biological Chemistry·Ruth A CraggDianne Ford
Jun 20, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Michael A BurkeJanice E Knepper
Feb 20, 2004·Journal of Mammary Gland Biology and Neoplasia·Richard W E Clarkson, Christine J Watson
May 14, 2004·The Journal of Biological Chemistry·Paul PodsiadloOfer Blum
Jan 7, 2005·American Journal of Physiology. Cell Physiology·Shannon L Kelleher, Bo Lönnerdal
Jan 8, 2005·The Journal of Biological Chemistry·Jian CaoChristian Chiarelli
Feb 12, 2005·The Journal of Biological Chemistry·Liping HuangYan Yiu Yu
Apr 19, 2006·Journal of Cellular Biochemistry·Tomoki KimuraMasakazu Isobe
Jun 2, 2006·Chemico-biological Interactions·Alexei TermanUlf T Brunk
Jun 3, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Shannon L Kelleher, Bo Lönnerdal
Aug 19, 2006·Differentiation; Research in Biological Diversity·Mark D SternlichtZena Werb
Aug 23, 2006·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Artur Krezel, Wolfgang Maret
Dec 1, 2006·Journal of Mammary Gland Biology and Neoplasia·James L McManamanEdwin C Thrower
Mar 7, 2007·Journal of Mammary Gland Biology and Neoplasia·Fiona O BaxterMaxine C Tevendale
Apr 14, 2007·Journal of Mammary Gland Biology and Neoplasia·Torsten SteinBarry A Gusterson

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Citations

Dec 4, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Shakhenabat KasanaWolfgang Maret
Mar 21, 2016·Cell Calcium·Kirill Kiselyov, Shmuel Muallem
Apr 10, 2016·Archives of Biochemistry and Biophysics·Sooyeon Lee, Shannon L Kelleher
Jan 27, 2015·Cell Calcium·Karina PeñaKirill Kiselyov
Oct 26, 2005·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Bo Lönnerdal
Jan 4, 2012·Seminars in Cancer Biology·Boris EngelsHans Schreiber
Mar 20, 2013·Molecular Aspects of Medicine·Jeeyon Jeong, David J Eide
Nov 14, 2018·Journal of Cellular Physiology·Lei TianQingzhang Li
Jun 30, 2016·American Journal of Physiology. Endocrinology and Metabolism·Sooyeon Lee, Shannon L Kelleher
Dec 9, 2017·Signal Transduction and Targeted Therapy·Elizabeth BafaroRobert E Dempski
May 4, 2016·The Journal of Biological Chemistry·Yarden GolanYehuda G Assaraf
Jul 28, 2019·Scientific Reports·Keigo NishidaToshio Hirano
Jun 8, 2021·Frontiers in Physiology·Lindsay Sawyer
Sep 30, 2021·Irish Journal of Medical Science·Xiaoqian WuZhichao Jiang
Aug 17, 2021·The Biochemical Journal·Amanda KowalczykKirill Kiselyov

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