May 1, 2010

The biomass objective function

Current Opinion in Microbiology
Adam M Feist, Bernhard Ø Palsson

Abstract

Flux balance analysis (FBA) is a mathematical approach for analyzing the flow of metabolites through a metabolic network. To computationally predict cell growth using FBA, one has to determine the biomass objective function that describes the rate at which all of the biomass precursors are made in the correct proportions. Here we review fundamental issues associated with its formulation and use to compute optimal growth states.

  • References34
  • Citations175

Mentioned in this Paper

Microorganism
Metabolic Process, Cellular
Alkalescens-Dispar Group
Metabolic Networks
Metabolic Networks and Pathways
Amino Acids, I.V. solution additive
Energy Metabolism
Protoplasm
Uptake
Protein Biosynthesis

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