PMID: 12787983Jun 6, 2003Paper

The biomechanical environment of a bone fracture and its influence upon the morphology of healing

Medical Engineering & Physics
Trevor Noel Gardner, Sanjay Mishra

Abstract

The mechanism by which mechanical stimulus of reparative tissues directs the pattern of healing of a bone fracture is not understood. Several hypotheses have been developed that predict the ossification pattern during healing for a given ambient mechanical environment. These have remained unproved because of the absence of data on stress fields in the reparative tissue of real fractures. The present study examines the predictive performance of the most recent hypothesis that was proposed by Claes and Heigele (J. Biomech. 32 (1999) 255), against measured and calculated data from the clinical fracture reported by Gardner et al. (J. Biomech. 33 (2000) 415). The hypothesis was used to predict ossification from the preceding stress and strain fields present in the FEM of Gardner et al. at four temporal stages during healing. Predictions were then compared with the observed differentiation and maturation. During early healing of the interfragmentary gap region, the hypothesis correctly predicted the formation of connective tissue and fibrocartilage, and during later healing it correctly predicted the beginning of endochondral ossification. At the periphery of the periosteal callus, the hypothesis correctly predicted intramembraneous ...Continue Reading

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Citations

Sep 17, 2004·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Peter AugatLutz Claes
Sep 17, 2008·Biomechanics and Modeling in Mechanobiology·E Reina-RomoM Doblaré
Jan 12, 2013·Biomechanics and Modeling in Mechanobiology·D ComiskeyJ O'Byrne
Jul 1, 2009·Integrative and Comparative Biology·Pui L Leong, Elise F Morgan
Aug 16, 2014·Medical Engineering & Physics·Muhammad Hanif RamleeTunku Kamarul
Nov 19, 2010·Computer Methods in Biomechanics and Biomedical Engineering·U SimonL Claes
Jan 1, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Allen E GoodshipClinton T Rubin
Aug 27, 2010·Journal of Biomedical Materials Research. Part a·You Zhi CaiHong Wei Ouyang
Aug 16, 2013·Journal of Biomedical Materials Research. Part a·Janin ReifenrathSilke Besdo
Aug 2, 2014·Medical Engineering & Physics·Feng ZhaoYubo Fan
Jun 5, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Scott D RamsayJ Paul Santerre
Mar 25, 2009·Orthopedics·Azadeh ShadmehrAlireza Sabbaghian
Dec 15, 2011·Materials·Berit UllmannAndrea Meyer-Lindenberg
Apr 6, 2012·Yonsei Medical Journal·Hoon ParkIck Hwan Yang
May 19, 2006·Journal of Biomechanical Engineering·M J Gómez-BenitoM Doblaré
Sep 17, 2016·Bone Research·Travis A BurgersBart O Williams
Mar 2, 2005·Clinical Orthopaedics and Related Research·Todd L BredbennerRoger G Wilber
Apr 22, 2018·Medical & Biological Engineering & Computing·Muhammad Hanif RamleeMohammed Rafiq Abdul Kadir
Sep 29, 2005·Injury·Toby Branfoot

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