The biomechanics of amnion rupture: an X-ray diffraction study

PloS One
Che J ConnonKeith M Meek

Abstract

Pre-term birth is the leading cause of perinatal and neonatal mortality, 40% of which are attributed to the pre-term premature rupture of amnion. Rupture of amnion is thought to be associated with a corresponding decrease in the extracellular collagen content and/or increase in collagenase activity. However, there is very little information concerning the detailed organisation of fibrillar collagen in amnion and how this might influence rupture. Here we identify a loss of lattice like arrangement in collagen organisation from areas near to the rupture site, and present a 9% increase in fibril spacing and a 50% decrease in fibrillar organisation using quantitative measurements gained by transmission electron microscopy and the novel application of synchrotron X-ray diffraction. These data provide an accurate insight into the biomechanical process of amnion rupture and highlight X-ray diffraction as a new and powerful tool in our understanding of this process.

References

Feb 25, 1978·Journal of Molecular Biology·J M GoodfellowA E Woolgar
Apr 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J T HalaburtK Ohlsson
Apr 1, 1989·American Journal of Perinatology·M J Keirse
Dec 1, 1969·The Bulletin of Mathematical Biophysics·R A Farrell, R W Hart
Jul 14, 1981·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·R M Aspden, D W Hukins
Jan 1, 1981·Cell and Tissue Research·M N Bou-ResliM E Ibrahim
Jul 1, 1980·Journal of Reproduction and Fertility·N S Al-ZaidM E Ibrahim
Jun 1, 1997·American Journal of Respiratory Cell and Molecular Biology·J H YoonP Nettesheim
Mar 5, 1998·The New England Journal of Medicine·S Parry, J F Strauss
Jul 31, 1998·The New England Journal of Medicine·R L Goldenberg, D J Rouse
Jul 25, 1958·The Journal of Biophysical and Biochemical Cytology·M L WATSON
Jun 1, 1960·American Journal of Obstetrics and Gynecology·G L BOURNE
May 1, 1965·The Journal of Cell Biology·J H VENABLE, R COGGESHALL
Dec 12, 2003·Matrix Biology : Journal of the International Society for Matrix Biology·Keith M MeekWinston W-Y Kao
Apr 13, 2006·Journal of Synchrotron Radiation·R A LewisD R Dance

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Citations

Feb 7, 2009·Tissue Engineering. Part a·Jean-Jacques GicquelAndrew Hopkinson
Sep 30, 2008·Tissue Engineering. Part C, Methods·Andrew HopkinsonHarminder S Dua
Mar 6, 2013·Archives of Gynecology and Obstetrics·Aylin SaglamTamer Mungan
Oct 4, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·J S Cohain
Feb 26, 2016·Placenta·E M JoyceJ J Moore
Apr 22, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Liang JiaDavid L Kaplan
Oct 22, 2013·Journal of Biomedical Materials Research. Part a·Bernice WrightChe J Connon
Jul 3, 2013·Journal of Biomedical Materials Research. Part a·Xianghua XiaoShengli Mi
Mar 28, 2009·International Journal of Cancer. Journal International Du Cancer·Veronica J James
Jul 7, 2011·Journal of Biomedical Materials Research. Part a·Shengli MiChe John Connon
Dec 21, 2013·Microscopy Research and Technique·Yeon-Hee KimHun-Kuk Park
Dec 2, 2014·Tissue Engineering. Part B, Reviews·Chiara E GhezziDavid L Kaplan
Jan 24, 2012·Reproductive Sciences·Jerome F Strauss
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Gerry ClareHarminder Dua
Dec 7, 2018·Tissue Engineering. Part a·Joana WittStefan Schrader
Feb 2, 2021·Frontiers in Bioengineering and Biotechnology·Adelheid WeidingerAsmita Banerjee
Sep 21, 2021·Experimental and Therapeutic Medicine·Aida PetcaMona Elena Zvanca

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Methods Mentioned

BETA
X-ray
electron microscopy
transmission electron microscopy
Caesarean section

Software Mentioned

Image J

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