The biosynthetic gene cluster for the beta-lactam antibiotic tabtoxin in Pseudomonas syringae

The Journal of Antibiotics
Thomas G Kinscherf, David K Willis

Abstract

DNA sequence analysis revealed that the biosynthetic genes of the unusual beta-lactam antibiotic tabtoxin reside at the att site adjacent to the lysC tRNA gene in Pseudomonas syringae BR2. ORFs encoded within the region included ones with similarity to beta-lactam synthase and clavaminic acid synthase, as well as amino acid synthesis enzymes. Novel ORFs were present in a portion of the biosynthetic region associated with a toxin hypersensitivity phenotype. Tabtoxin resistance was associated with a fragment containing a major facilitator superfamily (MFS) transporter gene.

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Citations

May 7, 2010·Journal of Industrial Microbiology & Biotechnology·Eric Cundliffe, Arnold L Demain
Mar 28, 2013·The Journal of Antibiotics·Kapil Tahlan, Susan E Jensen
May 17, 2011·Annual Review of Phytopathology·Heath E O'BrienDavid S Guttman
Sep 22, 2012·Biochemistry·Timothy A Wencewicz, Christopher T Walsh
May 29, 2018·Natural Product Reports·Patrick RabeChristopher T Lohans
Feb 12, 1998·Protein Science : a Publication of the Protein Society·M H EppinkW J Van Berkel
Oct 22, 2009·Natural Product Reports·Harald Gross, Joyce E Loper
Nov 3, 2009·Chembiochem : a European Journal of Chemical Biology·Mary L RaberCraig A Townsend
Nov 9, 2012·Natural Product Reports·Refaat B HamedChristopher J Schofield
Mar 23, 2017·Angewandte Chemie·Roderich D Süssmuth, Andi Mainz
Apr 10, 2019·Microbiology·Emmanuele Severi, Gavin H Thomas
Jul 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Trevor A Zandi, Craig A Townsend
Oct 19, 2017·Biochemistry·Garrett J PatrickTimothy A Wencewicz

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