The biosynthetic pathway of FK506 and its engineering: from past achievements to future prospects

Journal of Industrial Microbiology & Biotechnology
Yeon Hee BanYeo Joon Yoon

Abstract

FK506, a 23-membered macrolide produced by several Streptomyces species, is an immunosuppressant widely used to prevent the rejection of transplanted organs. In addition, FK506 and its analogs possess numerous promising therapeutic potentials including antifungal, neuroprotective, and neuroregenerative activities. Herein, we introduce the biological activities and mechanisms of action of FK506 and discuss recent progress made in understanding its biosynthetic pathway, improving production, and in the mutasynthesis of diverse analogs. Perspectives highlighting further strain improvement and structural diversification aimed at generating more analogs with improved pharmaceutical properties will be emphasized.

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Citations

Jan 26, 2017·The Journal of Antibiotics·Richard H Baltz
Oct 7, 2017·Applied Microbiology and Biotechnology·María Ordóñez-RoblesAntonio Rodríguez-García
Jun 26, 2018·Applied Microbiology and Biotechnology·Cheng WangShaoxiong Liang
Sep 6, 2018·Antimicrobial Agents and Chemotherapy·Yeonseon LeeYong-Sun Bahn
Nov 30, 2018·Journal of Industrial Microbiology & Biotechnology·Richard H Baltz
Mar 27, 2019·International Journal of Environmental Research and Public Health·Cheol ParkYung Hyun Choi
Jul 10, 2019·Frontiers in Microbiology·Janette V PhamYeo Joon Yoon
Nov 20, 2020·ChemMedChem·Lea WinandMarkus Nett
Nov 17, 2020·Frontiers in Molecular Biosciences·Sandeep VellankiSoo Chan Lee
Jul 20, 2021·Journal of Industrial Microbiology & Biotechnology·Richard H Baltz
Jul 20, 2019·Journal of Natural Products·Ji Yoon BeomYeo Joon Yoon

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