PMID: 7414618Jul 1, 1980

The biotransformation and disposition of bronopol following topical and intravenous administration to rats

Toxicology Letters
H S Buttar, R H Downie

Abstract

Approx. 40% of the topically applied dose of antibacterial agent [14C] bronopol([14C]BP) was absorbed through the rat skin within 24 h. Of the applied radioactivity, about 19% was excreted in the urine, feces and expired air. The 24 h recoveries of 14C in the urine and expired air were 15 and 2%, respectively, of the dose applied to the skin, and 74 and 9%, respectively, of the dose given intravenously. The TLC of the urines showed three metabolites, but no unchanged [14C]BP in both groups. The results suggest that rat skin is quite permeable to bronopol.

References

Jan 1, 1978·Biochemical Pharmacology·V UllrichP Weber
Jun 1, 1976·Food and Cosmetics Toxicology·P C RisdallL F Chasselaud
Jun 1, 1973·British Journal of Pharmacology·H S ButtarB H Thomas
Dec 1, 1964·The Journal of Pharmacy and Pharmacology·B CroshawB LESSEL

Citations

Jan 9, 2013·Journal of Agricultural and Food Chemistry·David J Smith, Robin C Anderson

Related Concepts

Bronopol
Administration, Topical
Microbicides
Metabolic Biotransformation
Intravenous Injections
Pharmaceutic Aids
Pharmaceutical Preservatives
Propylene Glycols
Skin Absorption
Drug or Chemical Tissue Distribution

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