PMID: 3773525Oct 1, 1986Paper

The biotransformation and urinary excretion of dexamethasone in equine male castrates

Journal of Steroid Biochemistry
M C DumasiaV Marks

Abstract

The pro-drugs of dexamethasone, a potent glucocorticoid, are frequently used as anti-inflammatory steroids in equine veterinary practice. In the present study the biotransformation and urinary excretion of tritium labelled dexamethasone were investigated in cross-bred castrated male horses after therapeutic doses. Between 40-50% of the administered radioactivity was excreted in the urine within 24 h; a further 10% being excreted over the next 3 days. The urinary radioactivity was largely excreted in the unconjugated steroid fraction. In the first 24 h urine sample, 26-36% of the total dose was recovered in the unconjugated fraction, 8-13% in the conjugated fraction and about 5% was unextractable from the urine. The metabolites identified by microchemical transformations and thin-layer chromatography were unchanged dexamethasone, 17-oxodexamethasone, 11-dehydrodexamethasone, 20-dihydrodexamethasone, 6-hydroxydexamethasone and 6-hydroxy-17-oxodexamethasone together accounting for approx 60% of the urinary activity. About 25% of the urinary radioactivity associated with polar metabolites still remains unidentified.

References

Aug 1, 1975·Journal of Pharmaceutical Sciences·K J KripalaniE C Schreiber
May 1, 1977·Journal of Clinical Pharmacology·S M BrooksP Altenau
May 21, 1977·The Veterinary Record·D I Chapman, J Whiteside
Jan 1, 1976·Biochemical Society Transactions·M C DumasiaM S Moss
Dec 20, 1976·Nihon Naibunpi Gakkai zasshi·T Mineo
Jan 1, 1975·Journal of Steroid Biochemistry·J EnglishV Marks
Jan 1, 1975·Dermatologica·E Seutter
Jun 1, 1973·The Biochemical Journal·M C DumasiaC O'Connor
Jan 1, 1972·The Journal of Clinical Endocrinology and Metabolism·N HaqueL J Sholiton
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Feb 1, 1967·The Journal of Endocrinology·M S Moss, H J Rylance
Mar 1, 1982·Steroids·D S Skrabalak, G A Maylin
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Apr 1, 1964·Acta Endocrinologica·D MURPHYA M BETHEL

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