The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism

Annals of the New York Academy of Sciences
E H CorderH Braak

Abstract

Epidemiologic studies indicate that elderly women are at higher risk for Alzheimer disease compared to men. In order to pathologically verify this result, the extent of AD brain lesions (NFT and SP) was compared for men and women at each age, that is, at each decade from 25 years to 95 years, in a large sample of > 5000 routine autopsy cases. Women had more affected brain regions beginning in late middle age. They also had more extensive SP depositions throughout the brain compared to men at each early NFT stage I, II, and III. At later NFT stages IV, V, and VI both men and women had extensive SP deposits. The gender gap in SPs at early NFT stages was large and specific to women who carried the APOE4 allele (P <.001) and in addition to the acceleration in NFT stage also found for APOE4+ women.

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jul 1, 1997·Neurobiology of Aging·H Braak, E Braak
Jul 1, 1997·Neurobiology of Aging·W SilvermanJ Wegiel
Feb 2, 2000·European Archives of Psychiatry and Clinical Neuroscience·E BraakH Braak

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Citations

Oct 3, 2007·Archives of General Psychiatry·Sterling C JohnsonMark A Sager
Jun 9, 2012·Molecular Neurobiology·Amandine GrimmAnne Eckert
May 27, 2011·Nature Neuroscience·Lary C Walker, Mathias Jucker
May 9, 2006·Dementia and Geriatric Cognitive Disorders·C A GorrieP M E Waite
Aug 24, 2012·PLoS Computational Biology·Willem de HaanCornelis J Stam
Jun 16, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jessica S DamoiseauxUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 2, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sterling C JohnsonMark A Sager
Jul 6, 2013·AJNR. American Journal of Neuroradiology·D HollandUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Mar 14, 2014·Journal of the International Neuropsychological Society : JINS·Ozioma C OkonkwoSterling C Johnson
Jun 19, 2013·Molecular Neurobiology·Jung Hoon LeeMin Jae Lee
Dec 3, 2013·Brain Imaging and Behavior·Leo UngarMichael D Greicius
Jan 25, 2012·TheScientificWorldJournal·Timo GrimmerRobert Perneczky
Jun 24, 2014·Maturitas·Walter A RoccaVirginia M Miller
Sep 24, 2014·Brain Research Bulletin·Mrinmay ChakrabartiSwapan K Ray
Feb 4, 2016·Scientific Reports·Chunyu WangXiongwei Zhu
Feb 3, 2016·Journal of Alzheimer's Disease : JAD·Xiao LuoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Dec 4, 2015·Archives of Gerontology and Geriatrics·Tae-Won KimKwang-Soo Lee
May 5, 2012·Hormones and Behavior·Rebekah S Vest, Christian J Pike
Feb 24, 2010·Clinics in Geriatric Medicine·Nazem Bassil, John E Morley
Nov 3, 2009·Neuroscience Letters·Helen T ButlerDonald J Lehmann
May 12, 2009·Frontiers in Neuroendocrinology·Christian J PikeAnna M Barron
Mar 10, 2015·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Nobuhiko TaniuchiHachiro Sugimoto
Dec 22, 2015·Neurobiology of Aging·Mafalda CacciottoloCaleb E Finch
Mar 8, 2008·Neurobiology of Aging·Adam S FleisherRichard B Buxton
Mar 13, 2016·The Journal of Steroid Biochemistry and Molecular Biology·Brandalyn C RiedelRoberta Diaz Brinton
Jan 15, 2005·Neurobiology of Disease·Katrin SchuesselAnne Eckert
Oct 1, 2010·Neuropathology and Applied Neurobiology·J A R NicollUNKNOWN Medical Research Council Cognitive Function and Ageing Study
Mar 14, 2014·Annals of Neurology·Andre AltmannUNKNOWN Alzheimer's Disease Neuroimaging Initiative Investigators
Oct 26, 2006·The American Journal of Geriatric Pharmacotherapy·Wendy M Haywood, Elizabeta B Mukaetova-Ladinska
Nov 23, 2006·Neuroscience Letters·Daniel D BuchananGeorge D Mellick
Dec 26, 2013·Neuroscience Letters·Jacqueline KunzlerLeon M Tai
Apr 24, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Yan HuangYong-Xiang Zhang
Dec 4, 2013·NeuroImage·Silke MaturaJohannes Pantel
May 3, 2011·Neuropsychologia·Kerryn E PikeChristopher C Rowe
Mar 24, 2016·Journal of Alzheimer's Disease : JAD·Silke MaturaJohannes Pantel
May 4, 2016·Neuroscience and Biobehavioral Reviews·Amandine GrimmAnne Eckert
Nov 21, 2014·PLoS Computational Biology·Yasser Iturria-MedinaUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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