The Bipolarity Index: a clinician-rated measure of diagnostic confidence

Journal of Affective Disorders
Chris B AikenGary S Sachs

Abstract

The Bipolarity Index is a clinician-rated scale that rates cardinal features of the disorder across five domains: signs and symptoms, age of onset, course of illness, response to treatment, and family history. We tested the Index in routine clinical practice to identify the optimal cut-off for distinguishing bipolar from non-bipolar disorders. Sequential patients in a private practice were rated with the Bipolarity Index (n=1903) at intake. Diagnoses were made with the MINI-6.0.0 International Neuropsychiatric Interview according to DSM-IV-TR criteria, except that cases of antidepressant-induced mania and hypomania were included in the bipolar group. A subset completed the self-rated Mood Disorder Questionnaire (MDQ) (n=1620) or Bipolar Spectrum Diagnostic Scale (BSDS) (n=1179). The primary analysis compared Bipolarity Index scores for bipolar vs. non-bipolar patients using receiver operator curves (ROC) to determine the optimal cut-off score. Secondary outcomes repeated this analysis with the MDQ, MDQ-7 (using only the symptomatic items of the MDQ) and BSDS. At a cut-off of ≥50, the Bipolarity Index had a high sensitivity (0.91) and specificity (0.90). Optimal cut-offs for self-rated scales were: MDQ: ≥7 (sensitivity 0.74, spe...Continue Reading

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Citations

Jun 11, 2016·Journal of Affective Disorders·Yantao MaGary Sachs
Jun 4, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·V G Kaleda, V A Zyablov
Sep 19, 2019·Translational Psychiatry·Heather A BruceL Elliot Hong
Sep 24, 2020·Psychiatric Services : a Journal of the American Psychiatric Association·James PhelpsOlivia Pipitone
Jul 1, 2020·Frontiers in Psychiatry·Claire O'Donovan, Martin Alda
Nov 20, 2019·Translational Psychiatry·Yantao MaXin Yu
Feb 8, 2019·Perspectives in Psychiatric Care·Janiece E DeSocio
Jan 21, 2021·Scientific Reports·Arthur Dun Ping MakSing Lee

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Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.