The bisphosphonate olpadronate inhibits skeletal prostate cancer progression in a green fluorescent protein nude mouse model

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Meng YangRobert M Hoffman

Abstract

Metastatic bone disease is one of the major causes of morbidity and mortality in prostate cancer patients. Bisphosphonates are currently used to inhibit bone resorption and reduce tumor-induced skeletal complications. More effective bisphosphonates would enhance their clinical value. We tested several bisphosphonates in a green fluorescent protein (GFP)-expressing human prostate cancer nude mouse model. The in vivo effects of four bisphosphonates, including pamidronate, etidronic acid, and olpadronate, on bone tumor burden in mice intratibially inoculated with PC-3-GFP human prostate cancer cells were visualized by whole-body fluorescence imaging and X-ray. The PC-3-GFP cells produced extensive bone lesions when injected into the tibia of immunocompromised mice. The skeletal progression of the PC-3-GFP cell growth was monitored by GFP fluorescence and the bone destruction was evaluated by X-ray. We showed that 3,3-dimethylaminopropane-1-hydroxy-1,1-diphosphonic acid (olpadronate) was the most effective bisphosphonate treatment in reducing tumor burden as assessed by GFP imaging and radiography. The GFP tumor area and X-ray score significantly correlated. Reduced tumor growth in the bone was accompanied by reduced serum calcium,...Continue Reading

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Citations

Jan 24, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y LoriotK Fizazi
Oct 23, 2008·Clinical & Experimental Metastasis·Eric L KaijzelClemens W G M Löwik
Jun 29, 2014·The Journal of Surgical Research·Shinji MiwaRobert M Hoffman
Jan 5, 2010·Trends in Biotechnology·Marie K ReumannPhilipp Mayer-Kuckuk
Jul 3, 2015·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shinji MiwaRobert M Hoffman
Feb 17, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Robert M Hoffman
Oct 31, 2006·The Journal of Urology·Hardev PandhaKevin Harrington
Jan 30, 2013·Laboratory Investigation; a Journal of Technical Methods and Pathology·James J CodyJoanne T Douglas
Dec 3, 2008·European Journal of Gastroenterology & Hepatology·Bi-Wei YangWei-Zhong Wu
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Apr 25, 2018·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Andrea ManciniClaudio Festuccia
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May 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·Y LoriotK Fizazi

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