PMID: 11344044May 10, 2001Paper

The bisphosphonate zoledronate decreases type II collagen breakdown in patients with Paget's disease of bone

Bone
P GarneroP D Delmas

Abstract

Bisphosphonates have been suggested to be partially chondroprotective in animal models of arthritis. The aim of this study was to assess the short-term effect of the bisphosphonate zoledronate on type II collagen degradation in patients with Paget's disease of bone. Twenty-six patients with active Paget's disease who were a part of a double-blind, placebo-controlled, randomized study comparing the effects of several doses of a single injection of zoledronate, a potent bisphosphonate, were studied. Type II collagen destruction was assessed by urinary levels of type II collagen C-telopeptide (CTX-II) using a new immunoassay. Bone resorption was assessed by measuring the urinary excretion of nonisomerized type I collagen C-telopeptide (alpha CTX-I). Biochemical markers were measured at baseline and 5, 10, 30, and 60 days after injection. At baseline, no significant increase of CTX-II was observed in patients with Paget's disease compared with a group of 27 gender-and age-matched controls, in contrast to the ninefold (p < 0.0001) increase of urinary alpha CTX-I. After a single intravenous injection of zoledronate (200 or 400 microg), urinary CTX-II transiently decreased by a median of 25% 5 days after the injection of zoledronate (...Continue Reading

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Citations

Dec 25, 2003·Clinical Therapeutics·Edward C Li, Lisa E Davis
Mar 27, 2003·Journal of Autoimmunity·Marijke Van GhelueOle Petter Rekvig
Jan 23, 2003·Joint, Bone, Spine : Revue Du Rhumatisme·Patrick Garnero
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Sep 10, 2003·Current Opinion in Rheumatology·Patrick Garnero, Pierre D Delmas
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