The blessings and curses of intestinal inflammation.

Cell Host & Microbe
Sebastian E WinterAndreas J Bäumler

Abstract

The intestinal immune system has to strike a delicate balance between initiating inflammatory responses against invading bacterial pathogens and avoiding their induction against microbiota colonizing the lumen. Adequate inflammatory responses against bacterial invasion result in the lumenal secretion of antimicrobial peptides, as well as the release of cytokines in tissue that recruit and activate phagocytes. However, pathogens have evolved to utilize these environmental changes in the inflamed intestine to promote colonization. This review focuses on the costs and benefits of intestinal inflammation and the fine interplay between the host, its microbiota, and enteric pathogens.

References

Apr 1, 1992·Canadian Journal of Microbiology·A S BrecherW Hann
Jan 1, 1991·International Archives of Allergy and Applied Immunology·Q HamidP K Jeffery
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J R HumbertJ B Schmitz
Jul 1, 1972·The Journal of Infectious Diseases·G T KeuschH Sprinz
Jan 1, 1980·The Journal of Clinical Investigation·M A Horwitz, S C Silverstein
Mar 1, 1994·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L M NoriegaM Aoun
Mar 6, 2002·The Journal of Experimental Medicine·Mathias W HornefAgneta Richter-Dahlfors
Jan 16, 2003·The Journal of Biological Chemistry·Stephen E GirardinPhilippe J Sansonetti
Jan 18, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R L SantosL G Adams
Mar 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·K HantkeG Winkelmann
Sep 30, 2004·Nature Immunology·Akiko Iwasaki, Ruslan Medzhitov
Oct 19, 2004·Nature Immunology·Jérôme VialaRichard L Ferrero
Oct 23, 2004·The Journal of Infectious Diseases·Calman MacLennanDinakantha S Kumararatne
Mar 18, 2005·Annual Review of Immunology·Ren-Feng Guo, Peter A Ward
Apr 14, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Masayuki FukataMaria T Abreu
Oct 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael A FischbachKelly D Smith
Nov 23, 2006·Nature Medicine·Jason M BrenchleyDaniel C Douek
Apr 20, 2007·Current Biology : CB·Mark E WickhamB Brett Finlay
Sep 18, 2007·Immunologic Research·Pieter-Jan Haas, Jos van Strijp
Oct 4, 2007·The Journal of Biological Chemistry·Yao-Hui SunRenée M Tsolis
Feb 5, 2008·Cellular Microbiology·Bärbel StecherWolf-Dietrich Hardt
May 14, 2008·The Journal of Infection·Melita A Gordon
May 24, 2008·The Journal of Clinical Investigation·Nobuhiko KamadaToshifumi Hibi

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Citations

Mar 13, 2012·Inflammatory Bowel Diseases·Melania Scarpa, Eleni Stylianou
May 18, 2011·Infection and Immunity·A Marijke KeestraAndreas J Bäumler
Apr 19, 2012·PLoS Pathogens·Douglas M HeithoffMichael J Mahan
Aug 6, 2014·Cell Research·Marcel R de Zoete, Richard A Flavell
Oct 28, 2011·Current Opinion in Microbiology·Parameth ThiennimitrAndreas J Bäumler
Oct 12, 2010·Current Opinion in Microbiology·Hiroshi AshidaChihiro Sasakawa
Jul 12, 2011·Cellular Microbiology·Ivan GodinezAndreas J Bäumler
Aug 8, 2015·Biochemistry·Vivek NarayanK Sandeep Prabhu
Jul 8, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Olivier Restif, Andrea L Graham
Mar 4, 2017·International Journal of Molecular Sciences·Maria Elisa Drago-SerranoMireya de la Garza
Mar 25, 2017·International Journal of Environmental Research and Public Health·Akebe Luther King AbiaWouter Le Roux
Jan 13, 2018·FEMS Microbiology Reviews·Pascale VonaeschPhilippe J Sansonetti
Jun 27, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Josephine ThinwaPeter H Dube
Jul 29, 2017·Frontiers in Cellular and Infection Microbiology·Wolfgang EisenreichWerner Goebel
Oct 17, 2017·Frontiers in Cellular and Infection Microbiology·Bushra IlyasBrian K Coombes

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