Jan 1, 1988

The blocking effect of l-cis-diltiazem on the light-sensitive current of isolated rods of the tiger salamander

European Biophysics Journal : EBJ
G Rispoli, A Menini

Abstract

The effect of the organic compound l-cis-diltiazem on the light-sensitive current of isolated rods of the tiger salamander was analysed by rapidly changing the extracellular medium using the method of Hodgkin et al. (1985). Addition to the extracellular medium of small amounts of l-cis-diltiazem rapidly inhibits the photocurrent. Complete suppression of the current was observed with 1 mM l-cis-diltiazem. Half blockage of the photocurrent occurred with about 150 microM l-cis-diltiazem. The blocking effect of l-cis-diltiazem was enhanced by light and by a reduction of extracellular Na. A concentration of l-cis-diltiazem of 140 microM, which suppresses one third of the photocurrent, was able to completely suppress the photocurrent carried by Ba. It is suggested that l-cis-diltiazem blocks the light-sensitive channel, possibly competing with cyclic guanosine-3'-5'-monophosphate (cGMP) for an internal regulatory site.

  • References18
  • Citations12

Mentioned in this Paper

Guanosine
Molecular Stereochemistry
Extracellular
Calcium
Organic Chemicals
Ambystoma tigrinum
Electric Conductivity
Light
Visual Suppression
Aldizem

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