PMID: 489270Jul 1, 1979Paper

The blood-brain barrier: effects of nonionic contrast media with and without addition of Ca2+ and Mg2+

Investigative Radiology
K Golman

Abstract

Trypan blue and 197HgCl2 were used as markers of the increased leakage through the blood-brain barrier which developed after selective injection of different contrast media formulations into the internal carotid arteries of rabbits. Interest was focused on a new, experimental, nonionic medium (C-29) and possible effects resulting from the addition of Ca2+ and Mg2+ to nonionic contrast media. Using 197Hg, it was possible to quantitate the increase in extravasation produced by the contrast media. C-29 caused less damage than either metrizamide or meglumine iothalamate. The addition of Ca2+ and Mg2+ to nonionic contrast media seemed to stabilize the blood-brain barrier.

Citations

Jan 1, 1990·Neuroradiology·M J HilzK F Druschky
May 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·S E BäckP Nilsson-Ehle
May 29, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·S MollR Dietz

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