PMID: 6111172Aug 1, 1980Paper

The blood-brain barrier in adrenaline-induced hypertension. Circadian variations and modification by beta-adrenoreceptor antagonists

Acta Neurologica Scandinavica
B B Johansson, L Martinsson

Abstract

Rats were subjected to adrenaline-induced acute hypertension during either the day or night. Albumin leakage into the brain was studied with Evans blue and 125I labeled serum albumin. The leakage was significantly lower during the night than during the day (P less than 0.001). d,1-propranolol had a protective effect (P less than 0.001) during the day and a slight reduction of the radioactivity (P less than 0.05 in some parts of the brain) was obtained by metoprolol (10 mg/kg) but not by butoxamine (10 mg/kg). None of the drugs reduced the tracer leakage during the night. The results suggest that the degree of alertness is of importance for the function of the blood-brain barrier in acute hypertension. However, the present experimental situation does not allow a separation of the effect of alertness per se and dark/light cycles. The changed vulnerability during the night could be related to enhanced neuronal activity, altered beta-adrenoreceptor sensitivity or to hormonal factors.

References

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Citations

Sep 1, 1985·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·V A Murphy, C E Johanson
Aug 1, 1988·Hypertension·G L Baumbach, D D Heistad
Jan 1, 1983·Acta Medica Scandinavica. Supplementum·B B Johansson
Nov 4, 2000·Journal of Psychoactive Drugs·M C McBride
Jan 1, 1987·Journal of Neuro-oncology·F J VriesendorpD R Groothuis
Aug 15, 1996·Annals of the New York Academy of Sciences·F PortaluppiC Fersini
Dec 17, 2020·Proceedings. Biological Sciences·O Semyachkina-GlushkovskayaJ Kurths

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