PMID: 2110528May 1, 1990Paper

The blood-brain barrier protects foreign antigens in the brain from immune attack

Experimental Neurology
I F Pollack, R D Lund

Abstract

To examine the role of the blood-brain barrier (BBB) in maintaining immune privilege in the brain, the BBB in the region of stably integrated mouse neural grafts implanted in neonatal rat brains was transiently disrupted by intracarotid infusion of hypertonic mannitol. This led to graft rejection and to prominent expression of major histocompatibility complex (MHC) antigens on cells adjacent to the graft. Grafts in control animals receiving an intracarotid infusion of isotonic saline showed only rare MHC expression and no increased incidence of rejection. Opening the barrier in the absence of a graft caused neither MHC expression nor cellular infiltration within the brain, suggesting that the effects of the hypertonic infusion were not produced by an indirect injury-mediated effect on the host brain. We conclude that the integrity of the blood-brain barrier is an important factor in the relative immune privilege of nonsyngeneic neural grafts.

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Citations

Jul 1, 1995·Journal of Neuroimmunology·K AppelP J Gebicke-Haerter
Mar 1, 1997·Journal of Neuroimmunology·T M LitchfieldR D Lund
Mar 22, 2002·Progress in Retinal and Eye Research·Robert B Aramant, Magdalene J Seiler
Mar 31, 2010·Journal of Applied Measurement·Ulrich Müller, Willis F Overton
Aug 15, 1998·Annals of the New York Academy of Sciences·L Lorusso, M L Rossi
Nov 8, 2011·Immunotherapy·Judith LeiboviciJudith Sinai
Jan 5, 2002·Journal of Neurosurgery·M A ProescholdtE H Oldfield
Jun 1, 1997·Journal of Neuroimmunology·E B PedersenB Finsen
Mar 1, 1994·Journal of Neuroimmunology·P J Gebicke-HaerterM Berger
Sep 16, 2006·Immunological Reviews·Sharon M WahlNiki Moutsopoulos
May 2, 2015·Regenerative Medicine·Victoria H RobertonClaire M Kelly
Jul 30, 2003·Journal of Leukocyte Biology·R D LundJ M Lawrence
Oct 22, 1993·The Journal of Comparative Neurology·K Rao, R D Lund
Mar 22, 1991·The Journal of Comparative Neurology·J M Rosenstein
May 6, 2010·Expert Review of Clinical Immunology·Ashleigh S Boyd, Paul J Fairchild
Oct 13, 2020·American Journal of Clinical Oncology·Mark A D'Andrea, G Kesava Reddy
Nov 7, 2019·American Journal of Clinical Oncology·Mark A D'Andrea, G Kesava Reddy
Dec 29, 2020·Frontiers in Aging Neuroscience·Robert A Culibrk, Mariah S Hahn

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