Abstract
To study blood coagulation and microcirculatory disorders as a possible cause of transient dysfunctions of organs (the kidney, liver, heart, lung, etc.) in patients with ixodid tick-borne borreliosis caused by Borrelia miyamotoi (Bmt). SUBJECTS AND METHODS; Twenty-four patients with Lyme disease (LD) and 28 Bmt patients treated at Izhevsk City Hospital (Udmurtia) were examined in the study. Platelet counts and the presence of D-dimers were determined; activated partial thromboplastin time, prothrombin time, thrombin time, fibrinogen and antithrombin III levels, and Factor XIIa-dependent fibrin clot lysis time were measured. Slit lamp microscopy of the conjunctiva was. also carried out. Results. Platelet counts'were less than 150,000 per pL of blood in 43% of the Bmt patients. All the Bmt patients had at least one abnormal coagulation parameter of the eight ones that were tested; 64% of them had marked coagulation disorders with three or more abnormal laboratory findings. In contrast, all the eight parameters were normal in 71% of the LD patients. The other seven LD patients had only one or two abnormal coagulation parameters (p < 0.001 in comparison with Bmt patients). Microscopic examination of eye capillary blood flow reveale...Continue Reading
References
Oct 1, 1995·International Journal of Systematic Bacteriology·M FukunagaM Nakao
Nov 24, 1999·The Journal of Infectious Diseases·A Shamaei-TousiS Bergström
May 9, 2001·The Journal of Experimental Medicine·A Shamaei-TousiS Bergström
Jul 12, 2003·Blood·Kishore R AlugupalliJohn M Leong
Aug 31, 2006·Infection and Immunity·Nilay SethiDiego Cadavid
Aug 30, 2008·Infectious Disease Clinics of North America·Mark S DworkinStephanie M Borchardt
Jul 23, 2009·Current Opinion in Infectious Diseases·Christer LarssonSven Bergström
Nov 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Betty P GuoSven Bergström
Jul 7, 2011·Current Opinion in Hematology·Felicitas MüllerThomas Renné
Oct 18, 2011·Emerging Infectious Diseases·Alexander E PlatonovPeter J Krause
Jul 6, 2012·Blood Reviews·Raed Al DieriH Coenraad Hemker
Feb 15, 2013·Thrombosis and Haemostasis·Charles T Esmon
Dec 10, 2013·Hematology·Cheng Hock Toh, Yasir Alhamdi
Jan 11, 2014·Blood·Anton MatafonovDavid Gailani
May 13, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Alan G Barbour
May 17, 2014·Nature Reviews. Microbiology·Michael R Yeaman
Jun 25, 2014·Emerging Infectious Diseases·Peter J KrauseUNKNOWN Tick Borne Diseases Group
Jul 26, 2014·Emerging Infectious Diseases·Kozue SatoHiroki Kawabata
Oct 31, 2014·New Microbes and New Infections·S JahfariH Sprong
Feb 24, 2015·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P J KrauseA G Barbour
Apr 22, 2015·Trends in Parasitology·Alex WagemakersJoppe W R Hovius
Jun 9, 2015·Annals of Internal Medicine·Philip J MolloyVictor P Berardi