PMID: 5914257Sep 1, 1966

The blood flow and oxygen consumption of brown adipose tissue in the new-born rabbit

The Journal of Physiology
T Heim, D Hull

Abstract

1. A direct method for measuring venous outflow from brown adipose tissue in anaesthetized new-born rabbits is described.2. During noradrenaline infusion the mean blood flow through brown adipose tissue increased from 87 to 360 ml./100 g tissue (wet wt.).min, and the mean rate of oxygen consumption of brown adipose tissue rose from 9.3 to 60 ml. O(2)/100 g tissue.min.3. During cold exposure the mean blood flow through brown adipose tissue increased from 90 to 304 ml./100 g tissue.min.4. The mean cardiac output was 266 ml./kg body weight.min; during noradrenaline infusion it was 405 ml./kg body weight.min. At rest about one tenth, and during noradrenaline infusion about one quarter of the cardiac output went to brown adipose tissue.5. It was calculated that most of the extra oxygen consumed during the metabolic response of the anaesthetized new-born rabbit to noradrenaline infusion or cold exposure was consumed by brown adipose tissue.6. Hypoxia (breathing 10% O(2) in N(2)) greatly reduced the increase in oxygen consumption but not the increase in blood flow in brown adipose tissue caused by noradrenaline infusion.

Citations

Jan 1, 1970·Lipids·B A HorwitzR E Smith
Mar 1, 1990·Equine Veterinary Journal·J C Ousey
Feb 27, 2013·Journal of Magnetic Resonance Imaging : JMRI·Houchun H HuVicente Gilsanz
Jun 19, 2010·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·D-X TanR J Reiter
Jan 11, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Arjun Khanna, Rosa T Branca
Nov 27, 2014·Biological Reviews of the Cambridge Philosophical Society·Leslie A RowlandMuthu Periasamy
May 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Houchun H HuTim R Nagy
Jun 1, 1977·Toxicology and Applied Pharmacology·K T Kitchin, V DiStefano
Oct 1, 1982·British Journal of Obstetrics and Gynaecology·J W WladimiroffJ S McGhie
Jan 28, 2005·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Hirobumi Asakura
Sep 22, 1998·Developmental Psychobiology·M S Blumberg, G Sokoloff
Jan 1, 1972·Acta paediatrica Scandinavica·E RylanderJ Lind
Oct 15, 1972·Experientia·D D Schnakenberg, R A Hoffman
Dec 1, 1984·Journal of Pediatric Surgery·B M NourM I Rowe
Feb 1, 1968·Archives of Biochemistry and Biophysics·S PrusinerB M Paddle
Dec 20, 2017·Plastic and Reconstructive Surgery·Junrong CaiFeng Lu
Dec 12, 1997·FEBS Letters·A KoivistoJan Nedergaard
Jul 11, 2012·Circulation. Cardiovascular Imaging·David M BaronMarielle Scherrer-Crosbie
Oct 5, 2018·Journal of Applied Physiology·Ashley M LoevenLara R DeRuisseau
Jun 9, 1977·Nature·Jan NedergaardO Lindberg
Mar 5, 2015·American Journal of Physiology. Endocrinology and Metabolism·Gustavo Abreu-VieiraJan Nedergaard
May 17, 1969·Nature·G R Hervey
Jan 1, 1980·Zeitschrift für Tierphysiologie, Tierernährung und Futtermittelkunde·E A El-Harith, U ter Meulen
Apr 30, 2003·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·L Pacheco-CobosR Hudson
Nov 15, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sulleman S Malik, James E Fewell
Mar 1, 1969·The Proceedings of the Nutrition Society·D Hull
Feb 1, 1973·Biological Reviews of the Cambridge Philosophical Society·L Janský
Aug 18, 2020·Archives of Biochemistry and Biophysics·Mariami JasaszwiliMarek Skrzypski

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Fat Pad
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