The 'blood group O problem' in kidney transplantation--time to change?

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Petra GlanderLutz Liefeldt

Abstract

Patients with blood group O have disadvantages in the allocation of deceased donor organs in the Eurotransplant Kidney Allocation System and fewer ABO-compatible living donors. In order to investigate the consequences of this dilemma, we analysed the outcome of patients with blood group O in our transplantation programme. A single-centre analysis of 1186 waitlisted patients for first deceased donor kidney transplantations between 1996 and 2008 was performed, and the mechanisms of blood group-dependent differences for graft and recipient outcome were assessed. Median follow-up time until death or end of observation for all waitlisted patients was 66 months (range, 0-158 months) and for 589 recipients of a kidney graft was 61 months (range, 0-158 months). Patients with blood group O had significantly longer waiting times for deceased donor kidney grafts, compared to non-group O recipients (median waiting time, 85 vs 59 months). As a consequence, blood group O patients had an increased risk for death without transplantation (13.1% for O patients vs 9.6% for non-O patients; P < 0.05). Despite a good human leukocyte antigen match, graft outcome tended to be worse in O recipients; 14.1% (95% CI, 8.2-19.9%) of all O kidneys from decea...Continue Reading

References

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Citations

Apr 3, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Johan W de Fijter
Apr 8, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Allison TongJonathan C Craig
Jul 11, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Joke I RoodnatWillem Weimar
Oct 29, 2011·Clinical Transplantation·Robert R RedfieldPeter L Abt
Feb 4, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L LiefeldtK Budde
Sep 3, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Lutz LiefeldtPetra Glander
Aug 14, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Lu HuberKlemens Budde
Mar 5, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J I RoodnatW Weimar
Feb 3, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Lu HuberKlemens Budde
Jun 9, 2016·Langenbeck's Archives of Surgery·Anja GallinatGeorgios C Sotiropoulos
Dec 26, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sarah J KizilbashBlanche M Chavers
Apr 15, 2014·British Journal of Hospital Medicine·Jennifer HunterSanjay Sinha
Oct 28, 2011·The New England Journal of Medicine·Jagadeesh Bayry, Srini V Kaveri
May 21, 2021·PloS One·Juliana Feiman Sapiertein SilvaLuis Gustavo Modelli de Andrade
Jan 10, 2019··Abdallah SaffidineToby Walsh

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