The blue-light receptor YtvA from Bacillus subtilis is permanently incorporated into the stressosome independent of the illumination state

Biochemical and Biophysical Research Communications
Marcel JurkPeter Schmieder


Higher organisms as well as bacteria rely on information on the surrounding environment. In Bacillus subtilis, diverse extra-cellular stimuli are transformed into an intra-cellular response via a signal integration hub, called the stressosome. The subsequent signal transduction cascade initiates the general stress response (GSR). One of these stimuli is blue light, which is sensed by the bacterial photoreceptor YtvA. We report here that YtvA is permanently incorporated into the stressosome independent of its illumination state and that RsbT stimulation occurs without direct interaction between the kinase RsbT and YtvA but in a light dependent manner. Furthermore, we show that RsbRA adopts a scaffolding function inside the stressosome explaining on a molecular level why RsbRA is required for light-mediated stress response in vivo.


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Related Concepts

RsbR protein, Bacillus subtilis
RsbT protein, Bacillus subtilis
Natto Bacteria
Bacterial Proteins
Protein-Serine-Threonine Kinases
Bacillus subtilis
Signal Transduction
Biological Adaptation to Stress
Body Part

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