The blue-light receptor YtvA from Bacillus subtilis is permanently incorporated into the stressosome independent of the illumination state

Biochemical and Biophysical Research Communications
Marcel JurkPeter Schmieder

Abstract

Higher organisms as well as bacteria rely on information on the surrounding environment. In Bacillus subtilis, diverse extra-cellular stimuli are transformed into an intra-cellular response via a signal integration hub, called the stressosome. The subsequent signal transduction cascade initiates the general stress response (GSR). One of these stimuli is blue light, which is sensed by the bacterial photoreceptor YtvA. We report here that YtvA is permanently incorporated into the stressosome independent of its illumination state and that RsbT stimulation occurs without direct interaction between the kinase RsbT and YtvA but in a light dependent manner. Furthermore, we show that RsbRA adopts a scaffolding function inside the stressosome explaining on a molecular level why RsbRA is required for light-mediated stress response in vivo.

References

Mar 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·Sean Crosson, Keith Moffat
Jun 16, 2001·Advances in Microbial Physiology·Michael Hecker, Uwe Völker
Sep 3, 2003·Molecular Microbiology·Chien-Cheng ChenOlivier Delumeau
Nov 23, 2005·Proceedings of the National Academy of Sciences of the United States of America·James W MurrayRichard J Lewis
Aug 23, 2006·Journal of Bacteriology·Tatiana A GaidenkoChester W Price
Aug 23, 2006·Journal of Bacteriology·Marcela Avila-PérezRemco Kort
Sep 4, 2007·Journal of Molecular Biology·Andreas Möglich, Keith Moffat
Nov 24, 2007·Annual Review of Microbiology·Michael HeckerUwe Völker
Jul 8, 2009·The Journal of Biological Chemistry·Marcela Avila-PérezKlaas J Hellingwerf
Mar 11, 2011·Photochemistry and Photobiology·Yusuke Nakasone, Klaas J Hellingwerf
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Citations

Jul 21, 2015·Photochemistry and Photobiology·Jeroen B van der Steen, Klaas J Hellingwerf
Jul 4, 2015·Photochemistry and Photobiology·Aba LosiWolfgang Gärtner
Nov 20, 2016·Photochemistry and Photobiology·Aba Losi, Wolfgang Gärtner
Aug 4, 2018·Antioxidants & Redox Signaling·Emma SevillaMaría F Fillat
Jul 3, 2013·Molecular BioSystems·Jeroen B van der SteenKlaas J Hellingwerf

Related Concepts

RsbR protein, Bacillus subtilis
RsbT protein, Bacillus subtilis
Natto Bacteria
Bacterial Proteins
Phosphoproteins
Protein-Serine-Threonine Kinases
Bacillus subtilis
Signal Transduction
Biological Adaptation to Stress
Body Part

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