The BMP pathway: A unique tool to decode the origin and progression of leukemia

Experimental Hematology
Florence ZylbersztejnVéronique Maguer-Satta

Abstract

The microenvironment (niche) governs the fate of stem cells (SCs) by balancing self-renewal and differentiation. Increasing evidence indicates that the tumor niche plays an active role in cancer, but its important properties for tumor initiation progression and resistance remain to be identified. Clinical data show that leukemic stem cell (LSC) survival is responsible for disease persistence and drug resistance, probably due to their sustained interactions with the tumor niche. Bone morphogenetic protein (BMP) signaling is a key pathway controlling stem cells and their niche. BMP2 and BMP4 are important in both the normal and the cancer context. Several studies have revealed profound alterations of the BMP signaling in cancer SCs, with major deregulations of the BMP receptors and their downstream signaling elements. This was illustrated in the hematopoietic system by pioneer studies in chronic myelogenous leukemia that may now be expanded to acute myeloid leukemia and lymphoid leukemia, as reviewed here. At diagnosis, cells from the leukemic microenvironment are the major providers of soluble BMPs. Conversely, LSCs display altered receptors and downstream BMP signaling elements accompanied by altered functional responses to BMP...Continue Reading

Citations

Sep 26, 2019·Biochemical Society Transactions·Caroline Busch, Helen Wheadon
Mar 14, 2020·Biochemical Society Transactions·Sylvain Lefort, Véronique Maguer-Satta
Jul 11, 2019·Oncotarget·John T Butler, Peter Kurre
Apr 23, 2020·Frontiers in Oncology·Claire L IhlePhilip Owens
Dec 9, 2020·Scientific Reports·Kung-Chao ChangPo-Min Chiang
Nov 6, 2020·Nature Communications·Hyeyoon LeeChristof Niehrs

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