The bone morphogenetic protein-2/7 heterodimer is a stronger inducer of bone regeneration than the individual homodimers in a rat spinal fusion model

The Spine Journal : Official Journal of the North American Spine Society
Tokimitsu MorimotoH Yoshikawa

Abstract

Bone morphogenetic proteins (BMPs) are a group of dimeric growth factors that belong to the transforming growth factor super family and are capable of eliciting new bone formation. Previous studies have suggested that the coexpression of two different BMP genes in a cell can result in the production of BMP heterodimers that are more potent than homodimers. However, because of the difficulty in optimizing the level of BMP gene expression, the coexpression of two different BMP genes also produces BMP homodimers as a by-product. These homodimers could, in theory, interact with the heterodimers. To elucidate the effects of a BMP-2/7 heterodimer, which were investigated in depth using purified BMP-2/7 heterodimers, BMP-2 homodimers, and BMP-7 homodimers in a rat spinal fusion model. Bilateral posterolateral fusion at L4-L5 was performed in four different groups: control group animals were implanted with collagen carriers alone; BMP-7 group animals with collagen carriers+1 μg of BMP-7 homodimer; BMP-2 group animals with collagen carriers+1 μg of BMP-2 homodimer; and BMP-2/7 group animals with collagen carriers+1 μg of the BMP-2/7 heterodimer. The following assessments were performed: bone microstructural analysis of the fusion mass a...Continue Reading

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E A WangP LaPan
Nov 12, 1965·Science·M R Urist
Apr 26, 1995·Biochemical and Biophysical Research Communications·M HazamaY Fujisawa
May 25, 1995·Biochemical and Biophysical Research Communications·A AonoY Fujisawa
Feb 7, 2003·Journal of Spinal Disorders & Techniques·Michael L SalamonJustin Laubach
Dec 23, 2003·Cellular Signalling·Anja NoheNils O Petersen
May 5, 2004·The Journal of Cell Biology·Mitsuru HorikiNoriyuki Tsumaki
Nov 13, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wei ZhuChisa Hidaka
Jun 7, 2005·Cytokine & Growth Factor Reviews·Howard Seeherman, John M Wozney
Aug 23, 2008·Journal of Dental Research·J T KohR T Franceschi
Sep 23, 2008·The Spine Journal : Official Journal of the North American Spine Society·Masashi MiyazakiJeffrey C Wang
Jul 2, 2009·JAMA : the Journal of the American Medical Association·Kevin S CahillElizabeth B Claus
May 19, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Wellington K HsuErin L Hsu
Sep 6, 2013·The Journal of Bone and Joint Surgery. American Volume·Takashi KaitoJeffrey C Wang
Nov 20, 2013·Journal of Pharmacology & Pharmacotherapeutics·Jaykaran Charan, N D Kantharia

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Citations

May 19, 2017·Tissue Engineering. Part B, Reviews·Rui M DuarteJorge Correia-Pinto
Aug 23, 2017·ELife·Antonio GaleoneHamed Jafar-Nejad
Aug 30, 2018·Physiological Reviews·Jonathan W Lowery, Vicki Rosen
Mar 5, 2019·Stomatologii︠a︡·V S KuznetsovaA A Kulakov
Sep 26, 2019·Biochemical Society Transactions·Caroline Busch, Helen Wheadon
Feb 11, 2019·Acta orthopaedica et traumatologica turcica·Engin ÇetinAlpaslan Şenköylü
Dec 11, 2019·Cells·Joachim Nickel, Thomas D Mueller
Apr 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·Benjamin TajerMary C Mullins

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