PMID: 9541220Apr 16, 1998Paper

The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult

European Journal of Oral Sciences
J M Wozney

Abstract

Originally identified as the active components within osteoinductive extracts derived from bone, the BMPs now are known to include a large family of proteins within the TGF-beta superfamily of growth and differentiation factors. Members of the BMP family have been determined to be key signaling molecules in embryogenesis, in species ranging from Drosophila to humans. They are involved in delivering positional information, the development of hard tissues (both bones and teeth), as well as soft tissue types. When implanted into adult animals, several of the BMPs have been shown to initiate the complex cellular process resulting in the induction of bone through both the endochondral and intramembranous bone formation pathways. Preclinical studies have shown the ability of these factors to induce bone and heal large bony defects in a variety of models relevant to clinical problems in orthopedics, as well as the oral and maxillofacial/dental areas. For example, implantation of recombinant human BMP-2 (rhBMP-2) has been shown to augment the alveolar ridge in several animal models, and when placed in a periodontal environment to restore not only new bone, but also the attachment tissues. Results from ongoing clinical studies support t...Continue Reading

Citations

Aug 24, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Xiaotong WangYuewen Gong
Aug 16, 2000·Advanced Drug Delivery Reviews·S R WinnJ O Hollinger
Jul 14, 2001·Molecular and Cellular Endocrinology·H ChangM M Matzuk
Jul 14, 2009·Marine Biotechnology·Changzhong LiRongqing Zhang
Feb 9, 2008·Annals of Surgical Oncology·Kazuo MotoyamaMasaki Mori
Jan 25, 2006·Cell and Tissue Research·A NadiriH Lesot
Nov 2, 2004·Die Naturwissenschaften·Yukiyo Yamamoto, Michael Oelgeschläger
Aug 27, 2013·The Spine Journal : Official Journal of the North American Spine Society·Samuel KalbNicholas Theodore
Jun 9, 2000·Kidney International·P Ducy, G Karsenty
Sep 22, 2011·Dental Clinics of North America·Daniel B Spagnoli, Robert E Marx
Apr 16, 2011·Oral and Maxillofacial Surgery Clinics of North America·Daniel B Spagnoli, Robert E Marx
Jun 25, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ugur DeligezerNejat Dalay
Jul 6, 2010·Archives of Biochemistry and Biophysics·Sandro MazzaferroLida Tartaglione
May 11, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Hyunjung KoMiri Kim
Dec 17, 2009·Biochemical and Biophysical Research Communications·Wenfeng LiShuxun Hou
May 8, 2007·Micron : the International Research and Review Journal for Microscopy·João Paulo Mardegan IssaRubens Ferreira de Albuquerque
Dec 26, 2006·Journal of Bioscience and Bioengineering·Akira TachibanaKiyoshi Yamauchi
Dec 8, 2004·Stem Cells·Boon Chin HengEng Hin Lee
Jan 14, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Chung-Fang Lai, Su-Li Cheng
Mar 9, 2007·American Journal of Medical Genetics. Part a·Yolande van BeverWinnie Courtens
Sep 28, 2007·Journal of Biomedical Materials Research. Part a·C SchopperH Redl
Oct 13, 2006·Journal of Cellular Physiology·Samir M AbdelmagidFayez F Safadi
Mar 5, 2008·Journal of Biomedical Materials Research. Part a·Eiki YamachikaToshio Sugahara
Nov 3, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sarah B Wise, David W Stock
Nov 30, 2013·Journal of Biomedical Materials Research. Part a·Chia-Wei HsuJeffrey O Hollinger
Oct 8, 2014·Journal of Investigative and Clinical Dentistry·Thongchai NuntanaranontSurapong Vongvatcharanon
Nov 23, 2013·Journal of Cellular Physiology·Gregory R SondagFayez F Safadi
Apr 20, 2004·Biochemical and Biophysical Research Communications·Robert C OlneyEdward B Mougey
Mar 23, 2005·Pathologie-biologie·M-C DegatD Logeart-Avramoglou
Jan 4, 2007·The American Journal of Pathology·Ruth SchwaningerMarco G Cecchini
May 15, 2003·Osteoarthritis and Cartilage·E B Hunziker, I M K Driesang

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