The borderland of neuromyelitis optica.

Practical Neurology
Lucy A E MatthewsMartin R Turner

Abstract

Neuromyelitis optica (NMO), also known as Devic's disease, is an emerging clinical and pathological entity originally thought to be a variant of multiple sclerosis. Characterised by episodes of demyelination confined to the optic nerve and spinal cord, the discovery in such patients of antibodies to the aquaporin-4 channel has been largely responsible for defining the phenotype to date. Recently it has become clear that there is a borderland where there are patients with optic neuritis-only and myelitis-only forms of the disease, and these may be seronegative in the early phase. We describe two cases of optic neuritis-only NMO, and explore the current understanding of the diagnosis and spectrum of NMO disorders.

Citations

Apr 17, 2015·Multiple Sclerosis and Related Disorders·Lucy A Matthews, Jacqueline A Palace
May 8, 2013·Neurologia i neurochirurgia polska·Sławomir Michalak
Dec 7, 2010·Neurología : publicación oficial de la Sociedad Española de Neurología·J M García Domínguez, J Guzmán de Villoria Lebiedziejewski
May 24, 2012·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Mark J Morrow, Dean Wingerchuk

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