The bovine chemokine receptors and their mRNA abundance in mononuclear phagocytes.

BMC Genomics
Stephanie WiddisonTracey J Coffey

Abstract

The chemokine and chemokine receptor families play critical roles in both the healthy and diseased organism mediating the migration of cells. The chemokine system is complex in that multiple chemokines can bind to one chemokine receptor and vice versa. Although chemokine receptors have been well characterised in humans, the chemokine receptor repertoire of cattle is not well characterised and many sequences are yet to be experimentally validated. We have identified and sequenced bovine homologs to all identified functional human chemokine receptors. The bovine chemokine receptors show high levels of similarity to their human counterparts and similar genome arrangements. We have also characterised an additional bovine chemokine receptor, not present in the available genome sequence of humans or the more closely related pigs or horses. This receptor shows the highest level of similarity to CCR1 but shows significant differences in regions of the protein that are likely to be involved in ligand binding and signalling. We have also examined the mRNA abundance levels of all identified bovine chemokine receptors in mononuclear phagocytic cells. Considerable differences were observed in the mRNA abundance levels of the receptors, and ...Continue Reading

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Jun 27, 2013·Animal Health Research Reviews·Randall L Levings, James A Roth
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Datasets Mentioned

BETA
AAX08913

Methods Mentioned

BETA
PCR

Software Mentioned

ENSEMBL
Excel
ClustalW
SMART
BLAST
SequencherTM
GraphPad Prism
PHYLIP

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