PMID: 8971040Dec 1, 1996Paper

The bovine papillomavirus type 4 E8 protein binds to ductin and causes loss of gap junctional intercellular communication in primary fibroblasts

Journal of Virology
A FacciniJ D Pitts

Abstract

The E8 open reading frame of bovine papillomavirus type 4 encodes a small hydrophobic polypeptide which contributes to cell transformation by conferring anchorage-independent growth. Using an in vitro translation system, we show that the E8 polypeptide binds to ductin, the 16-kDa proteolipid that forms transmembrane channels in both gap junctions and vacuolar H+-ATPase. This association is not due to nonspecific hydrophobic interactions. PPA1, a Saccharomyces cerevisiae polypeptide homologous (with 25% identity) to ductin, does not complex with E8. Furthermore, E5B, structurally similar to E8 but with no transforming activity, does not form a complex with ductin. Primary bovine fibroblasts expressing E8 show a loss of gap junctional intercellular communication, and it is suggested that this results from the interaction between E8 and ductin.

References

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Citations

Jan 23, 2002·Oncogene·G Hossein AshrafiM Saveria Campo
May 16, 2008·Veterinary Research·Giuseppe Borzacchiello, Franco Roperto
Mar 23, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Eliseo A EugeninJoan W Berman
Mar 26, 2014·Transboundary and Emerging Diseases·F BocanetiG Borzacchiello
Jun 27, 2015·Frontiers in Cellular Neuroscience·Venkata Subba Rao AtluriMadhavan P N Nair
Apr 15, 2003·The Journal of General Virology·G ChambersL Nasir
Oct 18, 2008·Veterinary Dermatology·Lubna Nasir, M Saveria Campo
Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·G Hossein AshrafiM Saveria Campo
Jul 11, 2006·International Journal of Cancer. Journal International Du Cancer·G Hossein AshrafiM Saveria Campo
May 18, 2010·Archives of Virology·Hsiang-Jung HsiaoChi-Young Wang
May 23, 2014·Frontiers in Cellular Neuroscience·Paul Castellano, Eliseo A Eugenin
Feb 13, 2001·Journal of Virological Methods·N O FischerR I Woodruff
Sep 26, 2002·Virus Research·Philippa M O'Brien, M Saveria Campo
Feb 1, 2005·Virus Research·G Joan GrindlayVincent O'Brien
Aug 11, 2005·Molecular Cancer·Trond AasenMalcolm B Hodgins
Jul 21, 2010·Journal of Comparative Pathology·A CorteggioG Borzacchiello

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