The brain connectivity basis of semantic dementia: a selective review

CNS Neuroscience & Therapeutics
Qing YangYan-Chao Bi

Abstract

Semantic dementia (SD) is a neurodegenerative disorder characterized by the progressive loss of semantic memory and conceptual knowledge, coupled with asymmetric local brain atrophy concentrated in the anterior temporal lobe. Recent developments in neuroimaging techniques, especially the emergence of the "human connectomics," have made possible the study of the brain's functional and structural connections and the topological properties of the brain networks. Recent studies applying these techniques have shown that SD manifests extensive structural and functional connectivity alterations, providing important insights into the pathogenesis of SD and the neural basis of semantic memory in general. In this review, we present and discuss the existing findings about the brain connectivity changes in SD and how they might be related to the various behavioral deficits associated with this disorder and propose important unanswered questions that warrant further investigation.

References

Dec 1, 1992·Brain : a Journal of Neurology·J R HodgesE Funnell
Jun 5, 2003·Nature Reviews. Neuroscience·Denis Le Bihan
Oct 17, 2003·The New England Journal of Medicine·M-Marsel Mesulam
Mar 3, 2004·Annals of Neurology·Maria Luisa Gorno-TempiniBruce L Miller
Jun 5, 2004·Dementia and Geriatric Cognitive Disorders·Corey McMillanMurray Grossman
Nov 5, 2004·The European Journal of Neuroscience·R R DaviesJohn R Hodges
Oct 5, 2005·PLoS Computational Biology·Olaf SpornsRolf Kötter
Sep 19, 2006·Neurobiology of Aging·Béatrice DesgrangesFrancis Eustache
Oct 31, 2006·Brain : a Journal of Neurology·A-L R AdlamJ R Hodges
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Oct 20, 2007·Lancet Neurology·John R Hodges, Karalyn Patterson
Nov 21, 2007·Nature Reviews. Neuroscience·Karalyn PattersonTimothy T Rogers
Nov 11, 2008·Annals of Neurology·Gil D RabinoviciMaria Luisa Gorno-Tempini
Nov 22, 2008·Brain : a Journal of Neurology·Stephen M WilsonMaria Luisa Gorno-Tempini
Feb 5, 2009·Nature Reviews. Neuroscience·Ed Bullmore, Olaf Sporns
Mar 10, 2009·Journal of Neurology·Hugues DuffauEmmanuel Mandonnet
Mar 24, 2009·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Gorana PobricElizabeth Jefferies
Apr 21, 2009·Neuron·William W SeeleyMichael D Greicius
Aug 15, 2009·NeuroImage·Jonathan D RohrerJason D Warren
Sep 18, 2009·Brain : a Journal of Neurology·Federica AgostaMaria Luisa Gorno-Tempini
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
Feb 9, 2010·Nature Reviews. Neurology·Murray Grossman
Mar 9, 2010·Trends in Cognitive Sciences·Marcus E Raichle
Dec 15, 2010·Frontiers in Neuroscience·David MeunierEdward T Bullmore
Jan 12, 2011·Annual Review of Clinical Psychology·Moriah E Thomason, Paul M Thompson
Feb 15, 2011·Brain and Language·J M OgarM L Gorno-Tempini
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
May 27, 2011·Acta Neuropathologica·Keith A JosephsDennis W Dickson
Jun 8, 2011·Brain : a Journal of Neurology·Julio Acosta-CabroneroPeter J Nestor
Jun 15, 2011·Brain : a Journal of Neurology·Sebastiano GalantucciMaria Luisa Gorno-Tempini
Aug 23, 2011·Brain : a Journal of Neurology·Sharpley HsiehJohn R Hodges
Nov 29, 2011·NeuroImage·Denis Le Bihan, Heidi Johansen-Berg
Jul 1, 2009·Journal of Neurolinguistics·Sharon AshMurray Grossman
Mar 13, 2012·NeuroImage·Johanna C GollJason D Warren
Jan 1, 2011·Brain Connectivity·Karl J Friston

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Citations

Sep 22, 2015·CNS Neuroscience & Therapeutics·Yong He
Dec 6, 2016·Alzheimer's Research & Therapy·Ramon Landin-RomeroFiona Kumfor

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