PMID: 16627933Apr 22, 2006Paper

The brain-derived neurotrophic factor Val66Met polymorphism and rate of decline in Alzheimer's disease

Journal of Alzheimer's Disease : JAD
Jenny Y-J ChuuGreer M Murphy

Abstract

It is largely unknown why some patients with Alzheimer's disease (AD) decline cognitively more rapidly than others. Genetic differences among patients could influence rate of decline. Brain-derived neurotrophic factor (BDNF) is a neurotrophin important in the survival neurons and in memory function. BDNF levels are reduced in the brain in AD. The Val66Met polymorphism in the BDNF gene modifies neuronal BDNF secretion, and affects hippocampal function and memory performance. We tested the hypothesis that the BDNF Val66Met polymorphism influences rate of cognitive decline in AD. In a sample of 149 AD patients followed for an average of 3.9 years, we found no effect of BDNF Val66Met genotype on rate of change in the Mini Mental State Examination. Results were similar when we excluded patients taking an acetylcholinesterase inhibitor, those placed in a nursing home during the study, or those with a neuropathological diagnosis that included AD plus an entity other than AD. We also found no evidence that the effects of the BDNF Val66Met genotype depend on APOE genotype, which itself had no effect on rate of cognitive change. These findings suggest that the functional BDNF Val66Met variant is not a major determinant of rate of cogniti...Continue Reading

Citations

Feb 8, 2008·Genes, Brain, and Behavior·K SchindowskiL Buée
Oct 2, 2015·Aging and Disease·Josiane BudniAlexandra Ioppi Zugno
Mar 26, 2016·World Journal of Psychiatry·Lei ZhangXian-Zhang Hu
May 13, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joshua MatyiMona Buhusi
Feb 18, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Jean-Daniel AbrahamChantal Mourton-Gilles
Jun 6, 2009·Nature Reviews. Neurology·Chiara Zuccato, Elena Cattaneo
Dec 4, 2020·Aging and Disease·Rodrigo Urbina-VarelaAndrea Del Campo

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