PMID: 16628067Apr 22, 2006Paper

The brain erythropoietin system and its potential for therapeutic exploitation in brain disease

Journal of Neurosurgical Anesthesiology
Martin HasselblattAnna-Leena Siren

Abstract

The discovery of the broad neuroprotective potential of erythropoietin (EPO), an endogenous hematopoietic growth factor, has opened new therapeutic avenues in the treatment of brain diseases. EPO expression in the brain is induced by hypoxia. Practically all brain cells are capable of production and release of EPO and expression of its receptor. EPO exerts multifaceted protective effects on brain cells. It protects neuronal cells from noxious stimuli such as hypoxia, excess glutamate, serum deprivation or kainic acid exposure in vitro by targeting a variety of mechanisms and involves neuronal, glial and endothelial cell functions. In rodent models of ischemic stroke, EPO reduces infarct volume and improves functional outcome, but beneficial effects have also been observed in animal models of subarachnoid hemorrhage, intracerebral hemorrhage, traumatic brain injury, and spinal cord injury. EPO has a convenient therapeutic window upon ischemic stroke and favorable pharmacokinetics. Results from first therapeutic trials in humans are promising, but will need to be validated in larger trials. The safety profile and effectiveness of EPO in a wide variety of neurologic disease models make EPO a candidate compound for a potential firs...Continue Reading

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·A AnagnostouM Steiner
Oct 26, 1989·The New England Journal of Medicine·L T GoodnoughJ E Menitove
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·M DigicayliogluM Gassmann
Nov 1, 1994·Developmental Biology·Z Y LiuC T Noguchi
Mar 14, 1996·Nature·R GareauG R Brisson
Jul 15, 1996·European Journal of Biochemistry·R YamajiY Nakano
Mar 27, 1997·The New England Journal of Medicine·L T GoodnoughG L Andriole
Apr 1, 1996·The European Journal of Neuroscience·H H MartiM Gassmann
Jan 24, 1998·The Journal of Biological Chemistry·C LiuC T Noguchi
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·M SakanakaR Sasaki
Jun 12, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M BernaudinE Petit
Aug 11, 2000·European Journal of Pharmacology·G CalapaiM Buemi
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·M L BrinesA Cerami
Sep 23, 2000·Brain Research. Molecular Brain Research·K ChinC T Noguchi
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·A L SirénP Ghezzi
Apr 20, 2001·Acta Neuropathologica·A L SirénH Ehrenreich
Jul 27, 2001·Current Pharmaceutical Biotechnology·W Jelkmann
Nov 8, 2001·European Archives of Psychiatry and Clinical Neuroscience·H Ehrenreich, A L Sirén
Nov 8, 2001·European Archives of Psychiatry and Clinical Neuroscience·A L Sirén, H Ehrenreich
Feb 15, 2002·Current Opinion in Hematology·Mark J KouryStephen J Brandt
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Murat CelikMichael Brines
Mar 29, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Myriam BernaudinPascale Schumann-Bard
Apr 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Giovanni GrassoFrancesco Tomasello
May 4, 2002·Stroke; a Journal of Cerebral Circulation·P A RinglebW Hacke
Jun 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Alfredo GorioMichael Brines
Jul 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Anna K JunkDaniel M Rosenbaum
Jul 23, 2002·Trends in Immunology·John A Hamilton
Sep 3, 2002·Microvascular Research·Kai JaquetKarl-Heinz Kuck
Sep 25, 2002·The European Journal of Neuroscience·Mauro VairanoPierluigi Navarra
Dec 13, 2002·The New England Journal of Medicine·S Patricia Becerra, Juan Amaral
Mar 28, 2003·Biology of the Neonate·Abdullah KumralHasan Ozkan
May 15, 2003·Trends in Neurosciences·Ulrich DirnaglJohn M Hallenbeck

❮ Previous
Next ❯

Citations

Oct 19, 2006·Acta Neuropathologica·Martin HasselblattWolf-Rüdiger Schäbitz
Sep 25, 2012·Journal of Molecular Neuroscience : MN·Kun LiuYi-xue Xue
Dec 27, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anna-Leena SirénHannelore Ehrenreich
Dec 17, 2008·The Journal of Biological Chemistry·Iwona Hirschler-LaszkiewiczBarbara A Miller
Mar 23, 2011·Human Molecular Genetics·Pasqualina ColellaAlberto Auricchio
Sep 22, 2007·Critical Care Medicine·Aryeh Shander, Mazyar Javidroozi
Aug 13, 2008·The Journal of Trauma·Lena M NapolitanoHoward L Corwin
Jul 19, 2011·Neurology Research International·Stephana CarelliAlfredo Gorio
Nov 13, 2008·Neuroepidemiology·Raj C ShahDavid A Bennett
Sep 11, 2008·BMC Biology·Bartosz AdamcioHannelore Ehrenreich
Jan 29, 2011·Critical Care : the Official Journal of the Critical Care Forum·Hon-Kan YipWen-Neng Chang
Jun 23, 2010·European Journal of Endocrinology·P L KristensenB Thorsteinsson
Apr 8, 2014·Journal of Neurosurgery·Bernardo Oliveira RatilalHelder Dias Mota-Filipe
Jul 1, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heling ChuQiang Dong
Sep 19, 2009·Cellular and Molecular Life Sciences : CMLS·Arianne Monge NaldiDaniel Bodmer
Nov 8, 2011·Stem Cell Research·Brian SimsHarald Sontheimer
Mar 21, 2009·Neuropathology and Applied Neurobiology·O KüsterJ Schittenhelm
Jan 8, 2016·Brain Research·Sarah HellewellMaria Cristina Morganti-Kossmann
Dec 21, 2010·The Journal of Thoracic and Cardiovascular Surgery·Phillip D SmithT Brett Reece
Nov 26, 2015·Journal of Alzheimer's Disease : JAD·Martha DlugajUNKNOWN Heinz Nixdorf Recall Study Investigative Group
Jun 30, 2009·Experimental Eye Research·Maurice SchallenbergSolon Thanos
Feb 13, 2009·Diabetes Research and Clinical Practice·Peter Lommer KristensenBirger Thorsteinsson
Sep 16, 2008·Surgical Neurology·Antonios MammisAllen H Maniker
Jul 1, 2008·Molecular and Cellular Neurosciences·Mark I Ransome, Ann M Turnley
May 23, 2008·Best Practice & Research. Clinical Anaesthesiology·Jane Sturgess, Basil Matta
Mar 25, 2008·Acta Tropica·Anne-Lise BienvenuStéphane Picot
Dec 20, 2007·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Hannelore EhrenreichHenning Krampe
Jul 6, 2007·Journal of the Neurological Sciences·Michael ChoppJing Zhang
May 8, 2007·Critical Reviews in Oncology/hematology·Constance Tom NoguchiYi Jia
Aug 19, 2008·International Journal of Stroke : Official Journal of the International Stroke Society·Thomas I Nathaniel
Aug 20, 2009·International Journal of Stroke : Official Journal of the International Stroke Society·D M SeyfriedM Chopp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
M BrinesAnthony Cerami
Nature Reviews. Neuroscience
Michael Brines, Anthony Cerami
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Peter T TsaiS Thomas Carmichael
Proceedings of the National Academy of Sciences of the United States of America
A L SirénPietro Ghezzi
© 2022 Meta ULC. All rights reserved