The brain gene expression profile of dopamine D2/D3 receptors and associated signaling proteins following amphetamine self-administration

Neuroscience
H SunR Chen

Abstract

Persistent neuroadaptations following chronic psychostimulant exposure include reduced striatal dopamine D2 receptor (D2R) levels. The signaling of D2Rs is initiated by Gαi/o proteins and terminated by regulator of G protein signaling (RGS) proteins. The purpose of this study is to examine the association of the drug taking behavior and gene expression profile of D2/D3Rs, and their associated signaling proteins in the ventral tegmental area (VTA) and nucleus accumbens (NAc) using a rodent model of amphetamine (AMPH) self-administration. Rats were allowed to self-administer AMPH (0.187 mg/kg/infusion for a maximum of 40 injections in 6h daily sessions) for 5 days during which rats showed an escalated rate of AMPH intake across days. AMPH self-administration induced profound brain region-dependent alterations of the targeted genes. There was a positive correlation of the messenger ribonucleic acid (mRNA) levels of RGS10 between the VTA and the NAc in the control animals, which was abolished by AMPH self-administration. AMPH self-administration also produced a negative correlation of the mRNA levels of RGS7 and RGS19 between the two brain regions, which was not present in the control group. Furthermore, AMPH taking behavior was as...Continue Reading

References

Sep 15, 1993·Biological Psychiatry·J H Meador-WoodruffS J Watson
Dec 1, 1996·Alcoholism, Clinical and Experimental Research·N D VolkowK Piscani
May 1, 1997·Brain Research. Molecular Brain Research·D M SegalD C Mash
Jan 1, 1997·Critical Reviews in Neurobiology·R PicettiE Borrelli
Dec 1, 2001·Journal of Substance Abuse Treatment·C A Dackis, C P O'Brien
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 3, 2004·Brain Research. Molecular Brain Research·Christopher LarminieMartine Garnier
Sep 10, 2004·Molecular Biology of the Cell·Freddy JeanneteauPierre Sokoloff
Jun 14, 2005·International Journal of Biological Sciences·David P Siderovski, Francis S Willard
Aug 22, 2007·Psychopharmacology·Yu LiuDavid C S Roberts
Jan 26, 2008·The Journal of Pharmacology and Experimental Therapeutics·J Robert LaneGraeme Milligan
Jun 30, 2009·Biochemical Pharmacology·Jillian H Hurst, Shelley B Hooks
Mar 6, 2010·Annals of the New York Academy of Sciences·John Traynor
May 19, 2010·Journal of Neurochemistry·Jeremy CelverAbraham Kovoor
Jul 31, 2010·Science·Joshua W BuckholtzDavid H Zald
Feb 10, 2011·Pharmacological Reviews·Jean-Martin Beaulieu, Raul R Gainetdinov
Jul 12, 2011·Nature Neuroscience·Estefanía P BelloMarcelo Rubinstein
Jul 13, 2011·Molecular Psychiatry·G J WangJ S Fowler
Sep 8, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chengchun MinKyeong-Man Kim
Nov 21, 2012·The International Journal of Neuropsychopharmacology·Fabio FumagalliLuigi Cervo
Feb 12, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Erin S CalipariRong Chen
Apr 10, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Weng Heng Tang

❮ Previous
Next ❯

Citations

Apr 29, 2016·ACS Chemical Neuroscience·Michael F SalvatoreSara R Jones
Sep 10, 2020·Scientific Reports·Marie A DoyleMichelle S Mazei-Robison
Feb 24, 2017·Frontiers in Cellular Neuroscience·Ada Ledonne, Nicola B Mercuri
Jun 1, 2020·Molecular Pharmacology·Farhana SaklothVenetia Zachariou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here